Adult brain neurogenesis and psychiatry: a novel theory of depression
Adult brain neurogenesis and psychiatry: a novel theory of depression
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DOI：
10.1038/sj.mp.4000712
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发表时间：
2000-05-01
影响因子：
11
通讯作者：
Gage, FH
中科院分区：
文献类型：
--
作者：
Jacobs, BL;van Praag, H;Gage, FH
神经发生（新神经元的诞生）在许多动物物种（包括人类）的大脑中持续到出生后和成年。这在海马结构的齿状回中尤为突出。其中一个因素，有力地抑制成人神经发生是压力，可能是由于增加糖皮质激素释放。补充这一点，我们最近发现，增加大脑血清素水平提高齿状回神经发生的基础率。这些和其他数据使我们提出了以下关于临床抑郁症的理论。压力引起的齿状回神经发生减少是抑郁症发作的重要原因。反过来，增加多巴胺能神经传递的抑郁症治疗干预至少部分地通过增强齿状回神经发生起作用，从而促进抑郁症的恢复。因此，我们假设海马结构中神经发生的减弱和增强分别是临床抑郁症发作和恢复的重要因果因素。
Neurogenesis (the birth of new neurons) continues postnatally and into adulthood in the brains of many animal species, including humans. This is particularly prominent in the dentate gyrus of the hippocampal formation. One of the factors that potently suppresses adult neurogenesis is stress, probably due to increased glucocorticoid release. Complementing this, we have recently found that increasing brain levels of serotonin enhance the basal rate of dentate gyrus neurogenesis. These and other data have led us to propose the following theory regarding clinical depression. Stress-induced decreases in dentate gyrus neurogenesis are an important causal factor in precipitating episodes of depression. Reciprocally, therapeutic interventions for depression that increase serotonergic neurotransmission act at least in part by augmenting dentate gyrus neurogenesis and thereby promoting recovery from depression. Thus, we hypothesize that the waning and waxing of neurogenesis in the hippocampal formation are important causal factors, respectively, in the precipitation of, and recovery from, episodes of clinical depression.