Course of illness, hippocampal function, and hippocampal volume in major depression
Course of illness, hippocampal function, and hippocampal volume in major depression
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DOI：
10.1073/pnas.0337481100
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发表时间：
2003-02-04
影响因子：
11.1
通讯作者：
Young, LT
中科院分区：
文献类型：
--
作者：
MacQueen, GM;Campbell, S;Young, LT
研究已经检查了抑郁症受试者的海马功能和体积，但没有人系统地比较从未治疗过的首次发作患者与多次发作患者。我们试图比较海马功能，评估的表现依赖于海马回忆记忆测试，和海马体积，测量在1.5 T磁共振成像仪，在抑郁症受试者经历青春期后抑郁症发作。将20名首次发作抑郁症的从未接受过治疗的抑郁症受试者与匹配的健康对照受试者进行比较。17名抑郁症受试者与多个过去的抑郁症发作进行了比较，匹配的健康对照组和首次发病的患者。第一次和多次发作的抑郁症组海马功能障碍明显的几个测试的回忆记忆，只有抑郁症患者多次抑郁发作海马体积减少。曲线拟合分析显示，患病时间和海马体积之间存在显著的对数关系。海马体积的减少可能不会早于疾病发作，但体积可能在疾病发作后的最初几年以最大速度减少。
Studies have examined hippocampal function and volume in depressed subjects, but none have systematically compared never-treated first-episode patients with those who have had multiple episodes. We sought to compare hippocampal function, as assessed by performance on hippocampal-dependent recollection memory tests, and hippocampal volumes, as measured in a 1.5-T magnetic resonance imager, in depressed subjects experiencing a postpubertal onset of depression. Twenty never-treated depressed subjects in a first episode of depression were compared with matched healthy control subjects. Seventeen depressed subjects with multiple past episodes of depression were also compared with matched healthy controls and to the first-episode patients. Both first- and multiple-episode depressed groups had hippocampal dysfunction apparent on several tests of recollection memory; only depressed subjects with multiple depressive episodes had hippocampal volume reductions. Curve-fitting analysis revealed a significant logarithmic association between illness duration and hippocampal volume. Reductions in hippocampal volume may not antedate illness onset, but volume may decrease at the greatest rate in the early years after illness onset.