An (A-C)n dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients.
An (A-C)n dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients.
复制标题
醛糖还原酶基因 5 端的 (A-C)n 二核苷酸重复多态性标记与 NIDDM 患者的早发性糖尿病视网膜病变相关。
DOI：
10.2337/diabetes.44.7.727
复制
发表时间：
1995
期刊：
影响因子：
7.7
通讯作者：
S. S. Chung
中科院分区：
文献类型：
--
作者：
B. C. Ko;K. Lam;N. Wat;S. S. Chung
To study the relationship between the aldose reductase gene and diabetic complications, an (A-C)n dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of this gene was identified and studied. There are seven alleles at this locus with a polymorphism information content of 0.73 and a heterozygosity of 0.77 among the Chinese population in Hong Kong. One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication.
