GAP JUNCTIONS BETWEEN PHOTORECEPTOR CELLS IN VERTEBRATE RETINA
GAP JUNCTIONS BETWEEN PHOTORECEPTOR CELLS IN VERTEBRATE RETINA
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DOI：
10.1073/pnas.70.6.1677
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发表时间：
1973-01-01
影响因子：
11.1
通讯作者：
GILULA, NB
中科院分区：
文献类型：
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作者：
RAVIOLA, E;GILULA, NB
在视网膜的外丛状层，锥细胞的突触末梢彼此之间以及与杆状细胞末梢之间形成专门的连接。这些受体间连接的超微结构在猴子、兔子和海龟的视网膜中，通过嵌入标本的薄片和冷冻破裂技术进行了描述。锥到棒的连接处是接近膜的带状区域。在细胞间隙狭窄的两侧，连接膜包含一排位于断裂面a（细胞质小叶）的颗粒，而互补元素，一排单一凹陷，位于断裂面b。颗粒行被膜区域包围，该膜区域没有颗粒内含物，并具有致密细胞质物质的粘附层。锥-锥连接在某些地方与锥-杆连接相同，而在其他地方它们非常类似于典型的间隙连接（nexus）。因此，受体间连接代表了间隙连接的形态变异，并可能介导相邻感光细胞之间的电紧张耦合。
In the outer plexiform layer of the retina the synaptic endings of cone cells make specialized junctions with each other and with the endings of rod cells. The ultrastructure of these interreceptor junctions is described in retinas of monkeys, rabbits, and turtles, in thin sections of embedded specimens and by the freeze-fracturing technique. Cone-to-rod junctions are ribbon-like areas of close membrane approximation. On either side of the narrowing of the intercellular space, the junctional membranes contain a row of particles located on the fracture face A (cytoplasmic leaflet), while the complementary element, a row of single depressions, is located on fracture face B. The particle rows are surrounded by a membrane region that is devoid of particulate inclusions and bears an adherent layer of dense cytoplasmic material. Cone-to-cone junctions in some places are identical to cone-to-rod junctions, while in other places they closely resemble typical gap junctions (nexus). Interreceptor junctions, therefore, represent a morphological variant of the gap junction, and probably mediate electrotonic coupling between neighboring photoreceptor cells.