GENETIC DISSECTION OF AUTOIMMUNE TYPE-I DIABETES IN THE BB RAT
GENETIC DISSECTION OF AUTOIMMUNE TYPE-I DIABETES IN THE BB RAT
复制标题
DOI：
10.1038/ng0992-56
复制
发表时间：
1992-09-01
期刊：
影响因子：
30.8
通讯作者：
LANDER, ES
中科院分区：
文献类型：
--
作者：
JACOB, HJ;PETTERSSON, A;LANDER, ES
BB大鼠是胰岛素依赖型糖尿病的最佳模型之一，其发病和发病机制与人类疾病非常相似。一个不寻常的特征是严重的T细胞淋巴细胞减少症，这似乎是作为一种隐性性状遗传的，由一个单一的基因控制，Lyp。基于几个杂交的遗传分析，我们发现糖尿病的发展涉及至少三个基因：Lyp，它与4号染色体上的神经肽Y（Npy）基因紧密连锁，与20号染色体上的主要组织相容性复合体（MHC）基因连锁，以及第三个未定位的基因，Fischer大鼠品系携带赋予抗性的等位基因。
The BB rat is among the best models of insulin-dependent diabetes mellitus - with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.