INTRAMEMBRANE INTERACTIONS BETWEEN NEUROTENSIN RECEPTORS AND DOPAMINE D(2)-RECEPTORS AS A MAJOR MECHANISM FOR THE NEUROLEPTIC-LIKE ACTION OF NEUROTENSIN
INTRAMEMBRANE INTERACTIONS BETWEEN NEUROTENSIN RECEPTORS AND DOPAMINE D(2)-RECEPTORS AS A MAJOR MECHANISM FOR THE NEUROLEPTIC-LIKE ACTION OF NEUROTENSIN
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DOI：
10.1111/j.1749-6632.1992.tb27350.x
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发表时间：
1992-10-22
期刊：
影响因子：
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通讯作者：
BENFENATI, F
中科院分区：
文献类型：
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作者：
FUXE, K;VONEULER, G;BENFENATI, F
已有证据表明，NT的行为作用，诱导其神经安定样作用，可以解释的基础上NT-D2膜内受体-受体相互作用在基底神经节，无关的共存现象，导致降低亲和力和转导的D2激动剂结合位点。通过在突触前和突触后水平选择性地减少D2受体转导，NT受体似乎能够将DA突触转换为D1受体介导的转导，说明受体-受体相互作用如何增加中枢突触的功能可塑性（图12）。
Evidence has been presented that behavioral actions of NT, inducing its neuroleptic-like action, can be explained on the basis of NT-D2 intramembrane receptor-receptor interactions in the basal ganglia, unrelated to the coexistence phenomenon, leading to reduced affinity and transduction of the D2 agonist binding site. By reducing selectively D2 receptor transduction at the pre-and postsynaptic level, the NT receptor appears capable of switching the DA synapses towards a D1 receptor-mediated transduction, illustrating how receptor-receptor interactions can increase the functional plasticity of central synapses (FIG. 12).