Microvasculature: An essential component for organ-on-chip systems
Microvasculature: An essential component for organ-on-chip systems
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DOI：
10.1557/mrs.2013.286
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发表时间：
2014-01-01
期刊：
影响因子：
5
通讯作者：
Jeon, Noo Li
中科院分区：
文献类型：
--
作者：
Lee, Hyunjae;Chung, Minhwan;Jeon, Noo Li
提高器官芯片的生物学相关性是生物医学工程的主要问题之一。微血管系统与器官生命周期中的众多生物现象相关。尽管已经开发出许多体外微血管系统，但目前的器官芯片系统未能完全集成三维微血管系统，这导致系统与体内条件的相似性降低。在这篇综述中，我们提出微血管系统是芯片器官工程的重要组成部分，以实现更大的生物学相关性。综述了体外工程微血管的各种方法，以及最近工程化血管化器官芯片的代表性工作。还回顾了设计芯片器官的材料考虑因素。
Improving the biological relevance of organs-on-chips is one of the main issues in biomedical engineering. The microvascular system is related to numerous biological phenomena throughout the life of organs. Although many in vitro microvascular systems have been developed, current organ-on-chip systems fail to fully integrate three-dimensional microvasculature, which results in decreased similarity of the systems with in vivo conditions. In this review, we propose that the microvascular system is an essential component for engineering organs-on-chips to achieve greater biological relevance. Various methods for engineering microvessels in vitro are reviewed, as well as recent representative efforts to engineer vascularized organs-on-chips. Material considerations for designing organs-on-chips are also reviewed.