Telomere replication: poised but puzzling.
Telomere replication: poised but puzzling.
复制标题
端粒复制：平静但令人费解。
DOI：
10.1111/j.1582-4934.2010.01220.x
复制
发表时间：
2011
影响因子：
5.3
通讯作者：
Chai,Weihang
中科院分区：
文献类型：
--
作者：
Sampathi,Shilpa;Chai,Weihang
•Introduction‐Telomeres, telomerase and their roles in genome stability‐Telomere DNA replication: not a cake walk for the replication fork•Functions of replication proteins in telomere maintenance‐DNA polymerase a‐primase (pola/primase)‐Replication protein A‐RecQ helicases‐Flap endonuclease 1 (FEN1)‐Dna2•Functions of telomere binding proteins in telomere replication‐TRF1‐TRF2‐Apollo‐POT1•The delayed telomeric C‐strand synthesis at late S/G2 phase – an additional regulatory step of telomere maintenance‐The CST complex•Conclusions and perspectivesFaithful replication of chromosomes is essential for maintaining genome stability. Telomeres, the chromosomal termini, pose quite a challenge to replication machinery due to the complexity in their structures and sequences. Efficient and complete replication of chromosomes is critical to prevent aberrant telomeres as well as to avoid unnecessary loss of telomere DNA. Compelling evidence supports the emerging picture of synergistic actions between DNA replication proteins and telomere protective components in telomere synthesis. This review discusses the actions of various replication and telomere‐specific binding proteins that ensure accurate telomere replication and their roles in telomere maintenance and protection.
