The colorectal cancer epidemic: challenges and opportunities for primary, secondary and tertiary prevention.
The colorectal cancer epidemic: challenges and opportunities for primary, secondary and tertiary prevention.
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DOI：
10.1038/s41416-018-0264-x
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发表时间：
2018-10
影响因子：
8.8
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Brenner H;Chen C
结直肠癌（CRC）是全球最常见和最可预防的癌症之一，具有强大但严重错过的一级，二级和三级预防潜力。传统上，CRC发病率在富裕的西方国家最高，但随着世界许多其他地区的经济发展，它正在迅速增加。CRC与其他常见疾病共有几个主要风险因素，如吸烟，过度饮酒，缺乏身体活动和超重;因此，减少这些风险因素的一级预防工作预计将产生超越CRC预防的多种有益影响，并应具有较高的公共卫生影响。在越来越多的国家实施的有组织的筛查方案中，通过提供有效的筛查测试，如粪便免疫化学测试、柔性乙状结肠镜检查和结肠镜检查，也可以大幅降低CRC的发病率和死亡率。与大多数其他国家相比，具有早期和高有效筛查率的国家显示出CRC发病率和死亡率的大幅下降。最后，越来越多的证据表明，CRC患者的预后和生活质量可以通过三级预防措施得到实质性改善，例如给予低剂量阿司匹林和促进体力活动。
Colorectal cancer (CRC) is both one of the most common and one of the most preventable cancers globally, with powerful but strongly missed potential for primary, secondary and tertiary prevention. CRC incidence has traditionally been the highest in affluent Western countries, but it is now increasing rapidly with economic development in many other parts of the world. CRC shares several main risk factors, such as smoking, excessive alcohol consumption, physical inactivity and being overweight, with other common diseases; therefore, primary prevention efforts to reduce these risk factors are expected to have multiple beneficial effects that extend beyond CRC prevention, and should have high public health impact. A sizeable reduction in the incidence and mortality of CRC can also be achieved by offering effective screening tests, such as faecal immunochemical tests, flexible sigmoidoscopy and colonoscopy, in organised screening programmes which have been implemented in an increasing number of countries. Countries with early and high uptake rates of effective screening have exhibited major declines in CRC incidence and mortality, in contrast to most other countries. Finally, increasing evidence shows that the prognosis and quality of life of CRC patients can be substantially improved by tertiary prevention measures, such as the administration of low-dose aspirin and the promotion of physical activity.
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影响因子：
7.1
作者：
Carr, Prudence R.;Jansen, Lina;Hoffmeister, Michael
通讯作者：
Hoffmeister, Michael
影响因子：
7.7
作者：
Brenner, Hermann;Schrotz-King, Petra;Hoffmeister, Michael
通讯作者：
Hoffmeister, Michael
DOI：
10.1136/bmj.g2467
发表时间：
2014-04-09
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Brenner H;Stock C;Hoffmeister M
通讯作者：
Hoffmeister M
影响因子：
3.9
作者：
Brenner H;Chen H
通讯作者：
Chen H
影响因子：
7.2
作者：
Brenner, Hermann;Stock, Christian;Hoffmeister, Michael
通讯作者：
Hoffmeister, Michael