Reduced wound contraction after grafting of full-thickness burns with a collagen and chondroitin-6-sulfate (GAG) dermal skin substitute and coverage with biobrane.
Reduced wound contraction after grafting of full-thickness burns with a collagen and chondroitin-6-sulfate (GAG) dermal skin substitute and coverage with biobrane.
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DOI：
10.1097/00004630-198807000-00010
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发表时间：
1988-07-01
期刊：
影响因子：
--
通讯作者：
Hansbrough, J F
中科院分区：
文献类型：
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作者：
Boyce, S T;Glafkides, M C;Hansbrough, J F
全层烧伤破坏皮肤的表皮和真皮组织。本研究评价了胶原蛋白和6-硫酸软骨素真皮皮肤替代物（移植物），该皮肤替代物应用于切除的全层烧伤并覆盖有Biobrane。实验条件包括：（a）无烧伤，皮下植入移植物;（B）烧伤，切除，移植，用Biobrane和绷带覆盖;（c）烧伤，切除，无移植，用Biobrane和绷带覆盖;（d）仅烧伤。手术后41天，皮下植入（N = 3）移植物未引起覆盖皮肤的可检测收缩或坏死，而所有烧伤伤口均收缩。伤口测量（原始伤口尺寸的百分比）显示以下治疗之间的统计学显著差异：（a）移植物加Biobrane（N = 10），34%;（B）无移植物加Biobrane（N = 9），25%;（c）未治疗烧伤（N = 6），16%。通过Biobrane从伤口上自发脱离指示的愈合时间的半定量评价显示，移植的切除伤口平均愈合2.7周，而未移植的切除伤口平均愈合4.3周。移植和Biobrane覆盖后愈合伤口的组织学外观类似于无表皮附属结构的未受损皮肤。切除全层烧伤焦痂，然后用胶原蛋白和软骨素-6-硫酸盐真皮皮肤替代物移植，并用Biobrane覆盖，与未切除的伤口相比，在6周的观察期内减少了伤口收缩。与未移植的切除伤口相比，发生了更快和更完全的伤口愈合。
Full-thickness burns destroy both the epidermal and dermal tissues of the skin. This study evaluates a collagen and chondroitin-6-sulfate dermal skin substitute (graft) that was applied to excised full-thickness burns and covered with Biobrane. Experimental conditions included: (a) no burn, subcutaneous implantation of the graft; (b) burn, excision, graft, coverage with Biobrane and bandages; (c) burn, excision, no graft, coverage with Biobrane and bandages; (d) burn only. forty-one days post-surgery, subcutaneous implantation (N = 3) of the graft caused no detectable contraction or necrosis of the overlying skin, whereas all burn wounds contracted. Measurements of wounds (percentage of original wound size) showed statistically significant differences between the following treatments; (a) graft plus Biobrane (N = 10), 34%; (b) no graft plus Biobrane (N = 9), 25%; (c) untreated burns (N = 6), 16%. Semi-quantitative evaluation of time to healing indicated by spontaneous detachment of Biobrane from wounds showed that grafted, excised wounds healed in an average of 2.7 weeks, while ungrafted, excised wounds required an average of 4.3 weeks to heal. Histological appearance of healed wounds after grafting and coverage with Biobrane resembles undamaged skin without epidermal adnexal structures. Excision of full-thickness burn eschar, followed by grafting with a collagen and chondroitin-6-sulfate dermal skin substitute and coverage with Biobrane provides reduced wound contraction within a six-week period of observation compared to non-excised wounds. Both more rapid and more complete wound healing took place compared to excised wounds that were not grafted.