Distribution and roles of aquaporins in salivary glands
Distribution and roles of aquaporins in salivary glands
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DOI：
10.1016/j.bbamem.2006.01.022
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发表时间：
2006-08-01
影响因子：
3.4
通讯作者：
Steinfeld, Serge
中科院分区：
文献类型：
--
作者：
Delporte, Christine;Steinfeld, Serge
唾液腺参与唾液的分泌，众所周知，唾液参与口腔、口咽和食道内粘膜结构的保护和水化，启动消化，一些抗菌防御，以及保护免受化学和机械应激。唾液分泌是一种含有电解质和蛋白质混合物的水状液体，可被毒鼠碱和肾上腺素能激动剂刺激。由于水运动与唾液分泌有关，因此水通道蛋白(AQPs)在唾液腺中的表达、定位和功能已被研究。本文将对唾液腺中水通道蛋白的表达、定位和功能作用进行综述。AQP1、AQP5和AQP8的存在已被许多人普遍接受，而AQP3、AQP4、AQP6和AQP7的存在仍然存在争议。从功能上讲，AQP5似乎是迄今为止唯一一个在唾液分泌过程中明显发挥重要作用的AQP。在干旱条件下，水通道蛋白的表达和/或分布发生了改变。(C)2006爱思唯尔B.V.保留所有权利。
Salivary glands are involved in secretion of saliva, which is known to participate in the protection and hydratation of mucosal structures within the oral cavity, oropharynx and oesophagus, the initiation of digestion, some antimicrobial defence, and the protection from chemical and mechanical stress. Saliva secretion is a watery fluid containing electrolytes and a mixture of proteins and can be stimulated by muscarinic and adrenergic agonists. Since water movement is involved in saliva secretion, the expression, localization and function of aquaporins (AQPs) have been studied in salivary glands. This review will focus on the expression, localization and functional roles of the AQPs identified in salivary glands. The presence of AQP1, AQP5 and AQP8 has been generally accepted by many, while the presence of AQP3, AQP4, AQP6 and AQP7 still remains controversial. Functionally, AQP5 seems to be the only AQP thus far to be clearly playing a major role in the salivary secretion process. Modifications in AQPs expression and/or distribution have been reported in xerostomic conditions. (c) 2006 Elsevier B.V. All rights reserved.