Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography
Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography
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DOI：
10.1007/s00417-011-1708-7
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发表时间：
2011-10-01
影响因子：
2.7
通讯作者：
Yasuno, Yoshiaki
中科院分区：
文献类型：
--
作者：
Agawa, Tetsuya;Miura, Masahiro;Yasuno, Yoshiaki
我们用三维高穿透光学相干断层扫描（OCT）进行视网膜和脉络膜厚度测绘，并评估健康眼黄斑部脉络膜厚度分布。43名健康日本志愿者的43只眼睛用1060 nm扫频OCT进行评估。这些眼睛用三维光栅扫描协议进行扫描，并获得后部分的平均视网膜和脉络膜厚度。这些部门由早期治疗糖尿病研究（ETDRS）布局定义。根据年龄（23-56岁）、等效球镜屈光不正（+0.9 D和-10.3 D之间）和眼轴长度（22.9-27.6 mm）对这些数据进行比较。ETDRS区域的平均视网膜和脉络膜厚度分别为284 +/- 14 μ m和348 +/- 63 μ m。鼻内黄斑区和鼻外黄斑区的脉络膜平均厚度明显小于其他所有区域。大部分区域的脉络膜厚度与眼轴长度呈显著负相关，与屈光不正呈显著正相关。眼轴长（> 25.0mm）的眼，5个区域的平均脉络膜厚度与年龄呈显著负相关。各节段间脉络膜厚度变异系数与眼轴长度呈显著负相关，与屈光不正呈正相关。每个区域的平均视网膜厚度与平均脉络膜厚度、年龄、眼轴长度或屈光不正无显著相关性，脉络膜厚度图显示的分布与视网膜厚度图完全不同。脉络膜厚度随位置、眼轴长度、屈光不正和年龄而显著变化。在评估脉络膜厚度时应考虑这些变化。
We performed retinal and choroidal thickness mapping by three-dimensional high-penetration optical coherence tomography (OCT) and evaluated the choroidal thickness distribution throughout the macula in healthy eyes.Forty-three eyes of 43 healthy Japanese volunteers were evaluated by 1060-nm swept-source OCT. The eyes were scanned with a three-dimensional raster scanning protocol, and the mean retinal and choroidal thicknesses of the posterior sectors were obtained. The sectors were defined by the Early Treatment Diabetic Study (ETDRS) layout. These data were compared by age (23-56 years), spherical equivalent refractive error (between +0.9 D and -10.3 D), and axial length (22.9-27.6 mm).The mean retinal and choroidal thicknesses of the ETDRS area were 284 +/- 14 mu m and 348 +/- 63 mu m respectively. The mean regional choroidal thicknesses in the nasal inner macula and nasal outer macula were significantly smaller than those in all other sectors. The mean regional choroidal thickness in most sectors showed a significant negative correlation with axial length and a significant positive correlation with refractive error. In eyes with a long axial length (> 25.0 mm), the mean regional choroidal thickness of five sectors showed a significant negative correlation with age. The coefficient of variation of choroidal thickness between sectors showed a significant negative correlation with axial length, and a positive correlation with refractive error. The mean retinal thickness in each sector was not significantly correlated with the mean choroidal thickness, age, axial length, or refractive error.The choroidal thickness map showed a distribution entirely different from the retinal thickness map. Choroidal thickness varies significantly with location, axial length, refractive error, and age. These variations should be considered when evaluating choroidal thickness.