LONGITUDINAL IMPACT OF YOGA ON CHEMOTHERAPY-RELATED COGNITIVE IMPAIRMENT AND QUALITY OF LIFE IN WOMEN WITH EARLY STAGE BREAST CANCER: A CASE SERIES
LONGITUDINAL IMPACT OF YOGA ON CHEMOTHERAPY-RELATED COGNITIVE IMPAIRMENT AND QUALITY OF LIFE IN WOMEN WITH EARLY STAGE BREAST CANCER: A CASE SERIES
复制标题
DOI：
10.1016/j.explore.2011.12.001
复制
发表时间：
2012-03-01
影响因子：
2.4
通讯作者：
O'Donnell, Laura
中科院分区：
文献类型：
--
作者：
Galantino, Mary Lou;Greene, Laurie;O'Donnell, Laura
目的：女性乳腺癌辅助化疗显着提高治愈率；然而，它与化疗相关的认知影响（CRCI）有关。文献为瑜伽干预对一般癌症人群的可行性和有效性提供了初步支持，然而，对照试验很少，也没有研究检验瑜伽对乳腺癌女性化疗期间认知的影响。本病例系列旨在确定瑜伽对乳腺癌幸存者 (BCS) 的认知、功能结果和生活质量 (QOL) 测量的影响。方法：四名在化疗前诊断为早期乳腺癌的女性在基线、化疗期间第 6 周和第 12 周以及研究结束后 1 个月和 3 个月时进行以下生理测量：功能伸展测试（平衡）和坐姿伸展测试（灵活性）以及 QOL、POMS （情绪）和 FACT-B (QOL)，处于基线。认知的主要结果是通过感知认知问卷（PCQ）和 CogState（一种计算机化的认知测量）来测量的。女性每周参加两次艾扬格瑜伽课程，持续 12 周。研究完成后进行了定性调查问卷，以确定瑜伽项目的好处和挑战。结果：四名患有 II 期乳腺癌的女性年龄在 44 岁至 65 岁之间。 CogState 计算机化测试显示，通过治疗和随访，不同认知领域发生了变化。随着时间的推移，平衡性、灵活性和生活质量也得到了改善。没有观察到不良事件。定性数据分析显示，瑜伽课程很有帮助，受试者继续练习瑜伽的练习要素，包括放松、呼吸和伸展。该研究最具挑战性的方面是由于各种医疗并发症造成的身体限制，包括疲劳、运动范围缩小和疼痛。结论：本病例系列表明，通过定量测量发现，瑜伽可能会影响化疗期间和化疗后认知的各个方面。女性将瑜伽描述为通过治疗轨迹改善生活质量的各个领域。这种身心干预可能会避免 CRCI；然而，还需要进一步研究瑜伽对接受辅助化疗的乳腺癌女性认知的影响，进行更多的随机对照试验。
Purpose: Adjuvant chemotherapy for women with breast cancer has significantly improved the cure rate; however, it has been associated with chemotherapy-related cognitive impact (CRCI). The literature provides preliminary support for the feasibility and efficacy of yoga interventions for the general cancer population, however, controlled trials are scarce and no studies have examined the effect of yoga on cognition for women with breast cancer during chemotherapy. This case series aims to identify the impact of yoga on measures of cognition, functional outcomes, and quality of life (QOL) for breast cancer survivors (BCS).Methods: Four women with a diagnosis of early-stage breast cancer prior to chemotherapy treatment were administered the following physiologic measures at baseline, 6, and 12 weeks during chemotherapy, and at one and three months after the conclusion of the study: Functional Reach test (balance) and Sit and Reach test (flexibility), and QOL, POMS (Mood) and FACT-B (QOL), at baseline. Primary outcomes of cognition were measured with the Perceived Cognition Questionnaire (PCQ) and CogState, a computerized measurement of cognition. Women attended an Iyengar-inspired yoga program twice a week for 12 weeks. Qualitative questionnaires were administered after the completion of the study to determine perceived benefits and challenges of the yoga program.Results: Four women with Stage II breast cancer ranged in age from 44-65 years. CogState computerized testing showed changes in varying domains of cognition through treatment and follow-up. Improved balance, flexibility, and QOL were also noted over time. No adverse events were observed. Analysis of qualitative data revealed the yoga classes were helpful and subjects continued the practice elements of yoga including relaxation, breathing, and stretching. The most challenging aspect of the study was physical limitations due to various medical complications and included fatigue, decreased range of motion, and pain.Conclusion: This case series suggests that yoga may impact various aspects of cognition during and after chemotherapy administration as noted through quantitative measures. Women describe yoga as improving various domains of QOL through the treatment trajectory. This mind-body intervention may stave off CRCI; however, further investigation is needed for additional randomized controlled trials on the effects of yoga on cognition for women with breast cancer undergoing adjuvant chemotherapy treatment.