Chronic lymphocytic leukaemia and small lymphocytic lymphoma: overview of the descriptive epidemiology
Chronic lymphocytic leukaemia and small lymphocytic lymphoma: overview of the descriptive epidemiology
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DOI：
10.1111/j.1365-2141.2007.06856.x
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发表时间：
2007-12-01
影响因子：
6.5
通讯作者：
Linet, Martha S.
中科院分区：
文献类型：
--
作者：
Dores, Graca A. M.;Anderson, William F.;Linet, Martha S.
2001年世界卫生组织的分类方案认为B细胞慢性淋巴细胞白血病（CLL）和小淋巴细胞淋巴瘤（SLL）在一个总的类别（CLL/SLL），因为共同的临床病理特征。我们在美国基于人群的监测、流行病学和最终结果计划中估计了CLL和SLL的年龄调整发病率（IR），以分别和联合分析CLL和SLL的模式。1993-2004年，CLL（n = 15 676）和SLL（n = 5382）的总体IR分别为3.83/100 000人-年和1.31/100 000人-年。男性中CLL/SLL的发生率比女性高90%，CLL（1.98）的男性：女性IR比率显著高于SLL（1.67）。与白人相比，黑人和亚洲/太平洋岛民的CLL/SLL IR分别低25%和77%。一个显着的报告延迟是明显的CLL，但不是SLL，所以CLL/SLL的时间趋势必须谨慎解释。在所有性别/种族组中，CLL和SLL IR随年龄呈指数级增加，CLL IR随年龄增长的增加比SLL更急剧。未来研究的途径包括评估癌症登记处的延迟和漏报，以及在流行病学研究中探索种族、性别和年龄的影响。
The 2001 World Health Organization classification scheme considers B-cell chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL) in an aggregate category (CLL/SLL) because of shared clinicopathological features. We have estimated age-adjusted incidence rates (IRs) of CLL and SLL in the population-based Surveillance, Epidemiology and End Results Program in the United States to analyse patterns of CLL and SLL separately and jointly. Age-standardized to the 2000 US population, overall IRs were 3.83 per 100 000 person-years for CLL (n = 15 676) and 1.31 for SLL (n = 5382) during 1993-2004. Incidence of the combined entity, CLL/SLL, was 90% higher among males compared to females, and the male:female IR ratio was significantly higher for CLL (1.98) than for SLL (1.67). CLL/SLL IRs were 25% and 77% lower among Blacks and Asian/Pacific Islanders, respectively, compared to Whites. A significant reporting delay was evident for CLL but not for SLL, so that CLL/SLL temporal trends must be interpreted cautiously. CLL and SLL IRs increased exponentially with age among all gender/race groups, with CLL IRs increasing more steeply with advancing age than SLL. Avenues of future research include assessment of delayed- and under-reporting to cancer registries and exploration of race, gender, and age effects in epidemiological studies.