Thetaburst TMS to the posterior superior temporal sulcus decreases resting-state fMRI connectivity across the face processing network
Thetaburst TMS to the posterior superior temporal sulcus decreases resting-state fMRI connectivity across the face processing network
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DOI：
10.1101/794578
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发表时间：
2019-10
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影响因子：
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通讯作者：
D. Handwerker;G. Ianni;B. Gutierrez;V. Roopchansingh;J. Gonzalez-Castillo;Gang Chen;P. Bandettini;Leslie G. Ungerleider;D. Pitcher
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文献类型：
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作者：
D. Handwerker;G. Ianni;B. Gutierrez;V. Roopchansingh;J. Gonzalez-Castillo;Gang Chen;P. Bandettini;Leslie G. Ungerleider;D. Pitcher
人类使用分布在大脑中的面部选择区域网络来识别人脸。神经心理学患者的研究表明，这个网络中节点的局灶性损伤会损害人脸识别，但这样的患者很少见。我们使用第一次经颅磁刺激(TBS)模拟了神经学上正常的人类参与者面部网络受损的影响。多回波功能磁共振成像(FMRI)数据在TBS投放前后通过面部选择性右侧颞叶上沟(RpSTS)或右侧运动皮质的对照部位收集。结果显示，通过rpSTS传递的TBS减少了整个扩展的面部处理网络的静息状态连接。这种连通性降低不仅在rpSTS和其他面孔选择区域之间观察到，而且在横跨大脑腹侧、内侧和外侧表面的非刺激面孔选择区域之间(例如，在右侧杏仁核与两侧梭形面区和枕面区之间)也被观察到。通过运动皮质传递的TBS在整个面部处理网络的静息状态连通性方面没有产生显著变化。这些结果表明，扰乱大脑网络中的单个节点会降低该网络中未直接受到刺激的分布式节点之间的功能连接。
Humans recognize faces using a network of face-selective regions distributed across the brain. Neuropsychological patient studies demonstrate that focal damage to nodes in this network can impair face recognition, but such patients are rare. We simulated the effects of damage to the face network in neurologically normal human participants using thetaburst transcranial magnetic stimulation (TBS). Multi-echo functional magnetic resonance imaging (fMRI) data were collected pre and post TBS delivery over the face-selective right superior temporal sulcus (rpSTS), or a control site in the right motor cortex. Results showed that TBS delivered over the rpSTS reduced resting-state connectivity across the extended face-processing network. This connectivity reduction was observed not only between the rpSTS and other face-selective areas, but also between non-stimulated face-selective areas across the ventral, medial and lateral brain surfaces (e.g. between the right amygdala and bilateral fusiform face areas and occipital face areas). TBS delivered over the motor cortex did not produce significant changes in resting-state connectivity across the face-processing network. These results demonstrate that disrupting a single node in a brain network can decrease the functional connectivity between the distributed nodes of that network that have not been directly stimulated.