NK-cell related neoplasms in Osaka, Japan
NK-cell related neoplasms in Osaka, Japan
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DOI：
10.1002/ajh.20091
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发表时间：
2004-07-01
影响因子：
12.8
通讯作者：
Aozasa, K
中科院分区：
文献类型：
--
作者：
Miyazato, H;Nakatsuka, S;Aozasa, K
对1999年至2003年日本大阪诊断和治疗的淋巴增殖性疾病中NK细胞相关肿瘤的发生率进行了估计。登记病例总数为1,400例，其中1,092例患者被诊断为恶性淋巴瘤。其中非霍奇金淋巴瘤 (NHL) 病例 987 例，霍奇金淋巴瘤 105 例 (9.6%)。免疫表型分析显示，743 名患者患有 B 细胞淋巴瘤，209 名患者患有 T/NK 细胞淋巴瘤。 T/NK细胞淋巴瘤中，有40例CD56免疫反应呈阳性，因此判断为NK/T细胞淋巴瘤。其中包括 1 例母细胞性 NK 细胞淋巴瘤和 39 例 NK/T 细胞淋巴瘤。根据主要病变部位，NK/T细胞淋巴瘤进一步分为三类：鼻型（23例）、非鼻结外型（11例）和结节型（5例）。原位杂交测定鼻型、非鼻型、淋巴结型EB病毒感染阳性率分别为83%、36%、25%。一名 EBV 阳性非鼻 NK/T 细胞淋巴瘤患者发现蚊子过敏。本研究表明，在日本 ATL 非流行地区，所有 NHL 中 NK 细胞相关肿瘤的发生率为 4%。 (C) 2004 Wiley-Liss, Inc.
The frequency of NK-cell related neoplasms was estimated among lymphoproliferative diseases diagnosed and treated in Osaka, Japan, from 1999 to 2003. The total number of registered cases was 1,400, among which 1,092 patients were diagnosed as having malignant lymphomas. There were 987 cases of non-Hodgkin's lymphoma (NHL) and 105 (9.6%) of Hodgkin's lymphoma. Immunophenotypic analysis revealed that 743 patients had B-cell lymphomas and 209 T/NK-cell lymphomas. Among the T/NK-cell lymphomas, 40 showed positive immunoreactivity for CD56, and thus they were judged to be NK/T-cell lymphomas. They included one blastic NK-cell lymphoma and 39 NK/Tcell lymphomas. NK/T-cell lymphomas were further divided into three categories based on the main site of lesions: nasal type (23 cases), non-nasal extranodal type (11 cases), and nodal type (5 cases). The positive rate of infection with the Epstein-Barr virus determined by in situ hybridization was 83%, 36%, and 25% in the nasal, non-nasal, and nodal type, respectively. A mosquito allergy was found in one patient with EBV-positive non-nasal NK/T-cell lymphoma. The present study showed that the frequency of NK-cell related neoplasms among all NHLs was 4% in an ATL-non-endemic area of Japan. (C) 2004 Wiley-Liss, Inc.