Pulsatile gonadotropin-releasing hormone treatment in idiopathic delayed puberty.
Pulsatile gonadotropin-releasing hormone treatment in idiopathic delayed puberty.
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特发性青春期延迟的脉冲促性腺激素释放激素治疗。
DOI：
10.1210/jcem-62-1-95
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
A. von zur Mühlen
中科院分区：
文献类型：
--
作者：
T. Wagner;G. Brabant;F. Warsch;R. Hesch;A. von zur Mühlen
特发性男性青春期延迟定义为青春期延迟超过16岁，青春期前睾酮水平正常，对GnRH的促性腺激素反应正常（不包括垂体衰竭），对单次hCG注射的雄激素反应正常（不包括睾丸间质细胞功能障碍），无严重疾病。10个男孩与这种情况下，评价他们的自发LH，FSH和PRL分泌模式在24小时采样期间（20分钟的时间间隔）。此后，所有患者均接受GnRH（25 ng/kg）脉冲输注治疗。每90分钟一次脉冲，持续10天。两组可通过其预处理LH分泌模式来区分。5例患者出现夜间LH水平搏动性升高，通常发生在青春期早期。其他5例患者没有这样的模式（青春期前型）。GnRH治疗导致两组LH和睾酮水平升高。在GnRH治疗后的观察期内，所有治疗前有夜间脉冲性LH分泌的患者都有稳定的青春期发育，而其他患者则没有。总之，在一些测试中，包括慢性脉冲式GnRH治疗10天，只有夜间LH分泌模式区分青春期延迟从永久性下丘脑性腺功能减退症的男孩。
Idiopathic delayed male puberty is defined as a delay of puberty beyond the age of 16, with prepubertal testosterone levels, normal gonadotropin responses to GnRH (excluding pituitary failure), and normal androgen responses to a single hCG injection (excluding testicular Leydig cell dysfunction), in absence of serious disease. Ten boys with this condition were evaluated as to their spontaneous LH, FSH, and PRL secretory patterns during a 24-h sampling period (20-min intervals). After this all patients were treated with pulsatile infusions of GnRH (25 ng/kg . pulse every 90 min for 10 days. Two groups could be distinguished by means of their pretreatment LH secretory pattern. Five patients had nighttime pulsatile elevation of LH levels, as usually occurs in early puberty. The other five patients did not have such a pattern (prepubertal type). The GnRH treatment resulted in increased LH and testosterone levels in both groups. All patients with pretreatment nighttime pulsatile LH secretion had steady pubertal development during the post-GnRH treatment observation period, whereas the other patients did not. In conclusion, among a number of tests, including chronic pulsatile GnRH treatment for 10 days, only the nocturnal LH secretory pattern differentiated delayed puberty from permanent hypothalamic hypogonadism in boys.
影响因子：
158.5
作者：
HOFFMAN, AR;CROWLEY, WF
通讯作者：
CROWLEY, WF
周期检测：一种估计血液激素和底物浓度间歇性波动的频率和幅度的技术。
影响因子：
4.8
作者：
Clifton,DK;Steiner,RA
通讯作者：
Steiner,RA