Micro- and macroscopically structured zwitterionic polymers with ultralow fouling property
Micro- and macroscopically structured zwitterionic polymers with ultralow fouling property
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DOI：
10.1016/j.jcis.2020.05.122
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发表时间：
2020-10-15
影响因子：
9.9
通讯作者：
Zheng, Jie
中科院分区：
文献类型：
--
作者：
Zhang, Dong;Ren, Baiping;Zheng, Jie
假设：多两性离子作为一种很有前途的材料，经常被用于构建具有优化构象和成分的防污表面，用于各种防污应用。虽然许多两性离子聚合物的防污能力已经被确定，但在不同尺度上两性离子聚合物的分子结构、表面水化性能和防污性能之间的确切关系仍然是难以捉摸的。实验:首先设计并合成了一种新的两性离子单体3-（4-（甲基丙烯氧基）-1-甲基-1-甲基-1-酰基）-丙烷-1-磺酸盐（MAMPS），然后利用SI-ATRP和非均相双网络（DN）水凝胶与琼脂网络结合，通过一锅加热-冷却-光聚合的方法在Au衬底上制备成均匀的聚合物刷。最后在微观和宏观尺度上评价了两种不同聚合物形态对蛋白质/细胞/细菌吸附的防污能力。结果：对于显微镜下的polyMAMPS刷，它们对未稀释的血清/血浆中的非特异性蛋白质吸附（0.3-5 ng/cm(2)），细胞粘附长达3天，临床相关的细菌附着72天，最佳膜厚度为20-40 nm。对于宏观琼脂/polyMAMPS DN水凝胶，它们也表现出比组织培养聚苯乙烯（TCPS）少约96%的蛋白质粘附。由聚mamps组成的不同结构材料在微观和宏观尺度上都表现出优异的固有防污性能，这可能与其两性离子基团的高水结合特性有关。PoIyMAMPS材料是常用的聚甲基丙烯酸亚砜甜菜碱（polySBMA）和聚甲基丙烯酸羧甜菜碱（polyCBMA）两性离子的替代品，在防污设计和应用方面具有很大的前景。(C) 2020爱思唯尔公司版权所有。
Hypothesis: Polyzwitterions as a promising class of materials are often used to construct antifouling surfaces with optimized conformation and compositions for a wide variety of antifouling applications. While numerous zwitterionic polymers have been identified for their antifouling capacity, the exact relationship among molecular structure, surface hydration property, and antifouling performance of zwitterionic polymers at different scales still remains elusive.Experiments: we first designed and synthesized a new zwitterionic monomer of 3-(4-(methacryloyloxy)-1-methylpiperidin-1-ium-1-yl)-propane-1-suljonate (MAMPS), then used MAMPS monomers to fabricate into homogenous polymer brushes on Au substrate using SI-ATRP and heterogeneous double-network (DN) hydrogels combining with Agar network via one-pot, heating-cooling-photopolymerization method, and finally evaluated their antifouling ability to resist the adsorption of protein/cell/bacteria on the two different polymer forms at microscopic and macroscopic scales.Findings: For microscopic polyMAMPS brushes, they exhibited excellent resistance to nonspecific protein adsorption from both undiluted blood serum/plasma (0.3-5 ng/cm(2)), cell adhesion up to 3 days, and clinically relevant bacterial attachment for 72 hat the optimal film thicknesses of 20-40 nm. For macroscopic Agar/polyMAMPS DN hydrogels, they also exhibited approximately 96% less protein adhesion than tissue culture polystyrene (TCPS). Different structured materials consisting of polyMAMPS at both micro- and macro-scales demonstrate its excellent, intrinsic antifouling property, which could be related to their highly water binding character of zwitterionic groups. PoIyMAMPS materials, alternative to commonly used poly(sulfobetaine methacrylate) (polySBMA) and poly(carboxybetaine methacrylate) (polyCBMA) zwitterions, hold great promise for antifouling designs and applications. (C) 2020 Elsevier Inc. All rights reserved.