Controllable hydrogen bonded self-association for the formation of multifunctional antimicrobial materials
Controllable hydrogen bonded self-association for the formation of multifunctional antimicrobial materials
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DOI：
10.1039/d0tb00875c
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发表时间：
2020-06-07
影响因子：
7
通讯作者：
Hiscock, Jennifer R.
中科院分区：
文献类型：
--
作者：
White, Lisa J.;Boles, Jessica E.;Hiscock, Jennifer R.
SSA是一类超分子自缔合两亲盐，其阴离子组分含有共价结合的氢键给体-受体基序。这导致了可以同时采用多种氢键模式的单体单元。以前的研究表明，SSA可以作为临床相关的耐甲氧西林金黄色葡萄球菌(MRSA)的抗菌剂。在这里，我们报告了一种固有的荧光SSA，它可以根据溶剂环境自结合产生二聚体、球形聚集体和水凝胶，同时保持对模式革兰氏阳性菌(MRSA)和革兰氏阴性菌(大肠杆菌)的抗菌活性。最后，我们展示了SSA超分子水凝胶对抗生素氨苄西林的耐受性，导致了对两种模式菌生长的增强抑制，并得出了初步的分子结构-物理化学性质-抗菌活性关系。
SSAs are a class of supramolecular self-associating amphiphilic salt, the anionic component of which contains a covalently bound hydrogen bond donor-acceptor motif. This results in a monomeric unit which can adopt multiple hydrogen bonding modes simultaneously. Previous investigations have shown examples of SSAs to act as antimicrobial agents against clinically relevant methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report an intrinsically fluorescent SSA which can self-associate producing dimers, spherical aggregates and hydrogels dependent on solvent environment, while retaining antimicrobial activity against both model Gram-positive (MRSA) and Gram-negative (Escherichia coli) bacteria. Finally, we demonstrate the SSA supramolecular hydrogel to tolerate the inclusion of the antibiotic ampicillin, leading to the enhanced inhibition of growth with both model bacteria, and derive initial molecular structure-physicochemical property-antimicrobial activity relationships.