Hydrodynamic lift of vesicles and red blood cells in flow from Fahrxus & Lindqvist to microfluidic cell sorting
Hydrodynamic lift of vesicles and red blood cells in flow from Fahrxus & Lindqvist to microfluidic cell sorting
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DOI：
10.1016/j.cis.2014.03.002
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发表时间：
2014-06-01
影响因子：
15.6
通讯作者：
Franke, Thomas
中科院分区：
文献类型：
--
作者：
Geislinger, Thomas M.;Franke, Thomas
流体中作用于细胞和粒子的流体动力升力一直受到医学、数学、物理学和工程学的关注。Fahrus和Lindqvist关于血液粘度随毛细血管直径变化的早期发现激发了广泛的实验和理论研究，以阐明潜在的物理原理。我们回顾了导致惯性和非惯性升力发现的这一历史发展，并阐明了这些力的起源，这些力仍然不完全清楚。利用微流体技术引起了大量新的见解，特别是在流场与可变形物体（如囊泡或红细胞）之间更复杂的相互作用方面。我们从单细胞动力学的研究到利用流体动力进行颗粒和细胞分选的微流体技术的最新发展。这种连续和无标签的芯片细胞分选设备有望彻底改变个性化护理点诊断的医学分析。我们介绍了各种基于水动力升力的技术的最新进展，并讨论了它们的优点和局限性。(C) 2014 Elsevier B.V.版权所有
Hydrodynamic lift forces acting on cells and particles in fluid flow receive ongoing attention from medicine, mathematics, physics and engineering. The early findings of Fahrus & Lindqvist on the viscosity change of blood with the diameter of capillaries motivated extensive studies both experimentally and theoretically to illuminate the underlying physics. We review this historical development that led to the discovery of the inertial and non-inertial lift forces and elucidate the origins of these forces that are still not entirely clear. Exploiting microfluidic techniques induced a tremendous amount of new insights especially into the more complex interactions between the flow field and deformable objects like vesicles or red blood cells. We trace the way from the investigation of single cell dynamics to the recent developments of microfluidic techniques for particle and cell sorting using hydrodynamic forces. Such continuous and label-free on-chip cell sorting devices promise to revolutionize medical analyses for personalized point-of-care diagnosis. We present the state-of-the-art of different hydrodynamic lift-based techniques and discuss their advantages and limitations. (C) 2014 Elsevier B.V. All rights reserved.