Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19.
Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19.
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DOI：
10.1158/2643-3230.bcd-20-0177
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发表时间：
2021-01
影响因子：
11.2
通讯作者：
Ahmed R
中科院分区：
文献类型：
--
作者：
Dhodapkar MV;Dhodapkar KM;Ahmed R
由于疾病相关和治疗相关的免疫功能障碍，血液恶性肿瘤患者对病毒感染的易感性增加，对当前疫苗的免疫反应不佳。这些考虑也可能影响新出现的COVID-19疫苗在这一患者群体中的疗效，因此有必要系统地研究这些患者的天然和疫苗诱导的病毒特异性免疫。
Patients with hematologic malignancies have increased susceptibility to viral infections and suboptimal immunologic responses to current vaccines due to both disease-associated and therapy-related immune dysfunction. These considerations may impact the efficacy of emerging COVID-19 vaccines in this patient population as well and warrant the need to systematically study natural and vaccine-induced virus-specific immunity in these patients.