Computer simulation of field distribution and excitation of denervated muscle fibers caused by surface electrodes
Computer simulation of field distribution and excitation of denervated muscle fibers caused by surface electrodes
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DOI：
10.1046/j.1525-1594.1999.06377.x
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发表时间：
1999-05-01
影响因子：
2.4
通讯作者：
Rattay, F
中科院分区：
文献类型：
--
作者：
Reichel, M;Mayr, W;Rattay, F
在这项研究的过程中，2个子模型已经开发和组合，2-D有限元建模的电位分布在人类大腿和霍奇金和赫胥黎（HH）型模型计算纤维激发和动作电位传播。为了借助激活函数确定目标肌肉纤维的兴奋，必须知道纤维在肌肉内的取向。沿着纤维的电场沿着必须分别作为所施加的电流和电极处的电势的函数来计算。肌纤维的兴奋在很宽的范围内变化，这取决于主动和被动膜参数以及细胞内和细胞外介质。持续的去神经支配导致肌肉细胞的衰退，并发生成纤维细胞的部分替代。这些组织的电激活更困难，并且需要持续时间高达200 ms且振幅为60-100 V的双相刺激脉冲来引起去神经肌肉的收缩。一个例子显示了场分布和模拟活动的一个代表性的肌肉纤维的良好训练的m。股直肌
In the course of this study, 2 submodels have been developed and combined, the 2-D finite element modeling of the electrical potential distribution in the human thigh and a Hodgkin and Huxley (HH) type model to calculate fiber excitation and action potential propagation. To determine the excitation of the target muscle fiber with the help of the activating function, the fiber's orientation within the muscle has to be known. The electric field along the fiber has to be calculated as a function of the applied electric current and the potential at the electrodes, respectively. The excitement of the muscle fibers varies across a wide range depending on the active and passive membrane parameters and the intracellular and extracellular mediums. Persisting denervation leads to a decay of muscle cells, and a partial substitution by fibroblasts occurs. The electrical activation of these tissues is more difficult, and biphasic stimulation pulses up to 200 ms in duration and 60-100 V in amplitude are needed to cause a contraction of the denervated muscle. An example shows the field distribution and the simulated activity in one representative muscle fiber of a well trained m. rectus femoris.