Enhanced Frontoparietal Synchronized Activation During the Wake-Sleep Transition in Patients with Primary Insomnia
Enhanced Frontoparietal Synchronized Activation During the Wake-Sleep Transition in Patients with Primary Insomnia
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DOI：
10.5665/sleep.1734
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发表时间：
2012-04-01
期刊：
影响因子：
5.6
通讯作者：
Bosch-Bayard, Jorge
中科院分区：
文献类型：
--
作者：
Corsi-Cabrera, Maria;Figueredo-Rodriguez, Pedro;Bosch-Bayard, Jorge
简介：认知和大脑过度激活与原发性失眠（PI）患者的入睡困难和睡眠错觉有关。激活和同步/时间耦合在额叶和额顶叶区域参与执行控制和内源性attention可能会牵连在这些symptoms.Methods：标准多导睡眠图（PSG）和脑电图（EEG）记录在10个未服药的年轻患者（年龄19-34岁）PI没有其他睡眠/医疗条件，并在10个匹配的对照组。绝对功率，时间耦合，地形源分布（可变分辨率电磁断层扫描或VARETA）获得的所有时间花费在清醒，第1阶段和第2阶段的觉醒-睡眠过渡期（WSTP），和前3个连续分钟的N3。评价主观睡眠质量和连续性。结果：与对照组相比，PI患者在清醒和第一阶段表现出明显更高的额叶β功率和电流密度，以及β和γ额顶颞耦合。结论：这些发现表明，PI患者的额叶失活和参与执行控制、注意力和自我意识的大脑区域的脱离受到损害。这种激活和连贯的网络在觉醒-睡眠过渡期（WSTP）的持续性可能有助于更好地理解入睡困难，睡眠错觉，以及一些PI患者经历的较轻，较差和非刷新睡眠的潜在机制。
Introduction: Cognitive and brain hyperactivation have been associated with trouble falling asleep and sleep misperception in patients with primary insomnia (PI). Activation and synchronization/temporal coupling in frontal and frontoparietal regions involved in executive control and endogenous attention might be implicated in these symptoms.Methods: Standard polysomnography (PSG) and electroencephalogram (EEG) were recorded in 10 unmedicated young patients (age 19-34 yr) with PI with no other sleep/medical condition, and in 10 matched control subjects. Absolute power, temporal coupling, and topographic source distribution (variable resolution electromagnetic tomography or VARETA) were obtained for all time spent in waking, Stage 1 and Stage 2 of the wake-sleep transition period (WSTP), and the first 3 consecutive min of N3. Subjective sleep quality and continuity were evaluated.Results: In comparison with control subjects, patients with PI exhibited significantly higher frontal beta power and current density, and beta and gamma frontoparietal temporal coupling during waking and Stage 1.Conclusion: These findings suggest that frontal deactivation and disengagement of brain regions involved in executive control, attention, and self-awareness are impaired in patients with PI. The persistence of this activated and coherent network during the wake-sleep transition period (WSTP) may contribute to a better understanding of underlying mechanisms involved in difficulty in falling asleep, in sleep misperception, and in the lighter, poorer, and nonrefreshing sleep experienced by some patients with PI.