Biodegradable poly(D,L-lactic acid)-poly(ethylene glycol)-monomethyl ether diblock copolymers:: structures and surface properties relevant to their use as biomaterials
Biodegradable poly(D,L-lactic acid)-poly(ethylene glycol)-monomethyl ether diblock copolymers:: structures and surface properties relevant to their use as biomaterials
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DOI：
10.1016/s0142-9612(00)00103-4
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发表时间：
2000-12-01
期刊：
影响因子：
14
通讯作者：
Göpferich, A
中科院分区：
文献类型：
--
作者：
Lucke, A;Tessmar, J;Göpferich, A
为了获得用于组织培养应用的具有可变表面性质的可生物降解的聚合物，将聚（乙二醇）嵌段以各种组合连接到聚（乳酸）嵌段。所得的聚（D，L-乳酸）-聚（乙二醇）-单甲基醚（Me.PEG-PLA）二嵌段共聚物进行全面的调查，关于他们的整体微观结构和表面性能，以评估其适用性的药物输送应用程序，以及用于制造支架的组织工程。从H-1-NMR，凝胶渗透色谱，广角X-射线衍射和调制差示扫描量热法得到的结果表明，聚合物的本体微观结构包含聚（乙二醇）-单甲醚（Me.PEG）域从聚（D，L-乳酸）（PLA）域的不同组成的二嵌段共聚物。原子力显微镜和X-射线光电子能谱的聚合物膜的表面的分析表明，有一个变量的Me。PEG链存在于聚合物表面上，这取决于聚合物的组合物。可以表明，在聚合物表面中的Me.PEG链的存在下，对两种模型肽（鲑鱼降钙素和人心房利钠肽）的吸附具有抑制作用。通过改变共聚物组成来改变聚合物本体微观结构和表面性能的可能性是其在药物输送和组织工程领域有效使用的先决条件。(C)2000 Elsevier Science Ltd.保留所有权利。
To obtain biodegradable polymers with variable surface properties for tissue culture applications, poly(ethylene glycol) blocks were attached to poly(lactic acid) blocks in a variety of combinations. The resulting poly(D,L-lactic acid)-poly(ethylene glycol)-monomethyl ether (Me.PEG-PLA) diblock copolymers were subject to comprehensive investigations concerning their bulk microstructure and surface properties to evaluate their suitability for drug delivery applications as well as for the manufacture of scaffolds in tissue engineering. Results obtained from H-1-NMR, gel permeation chromatography, wide angle X-ray diffraction and modulated differential scanning calorimetry revealed that the polymer bulk microstructure contains poly(ethylene glycol)-monomethyl ether (Me.PEG) domains segregated from poly(D,L-lactic acid) (PLA) domains varying with the composition of the diblock copolymers. Analysis of the surface of polymer films with atomic force microscopy and X-ray photoelectron spectroscopy indicated that there is a variable amount of Me.PEG chains present on the polymer surface, depending on the polymer composition. It could be shown that the presence of Me.PEG chains in the polymer surface had a suppressive effect on the adsorption of two model peptides (salmon calcitonin and human atrial natriuretic peptide). The possibility to modify polymer bulk microstructure as well as surface properties by variation of the copolymer composition is a prerequisite for their efficient use in the fields of drug delivery and tissue engineering. (C) 2000 Elsevier Science Ltd. AII rights reserved.