BCL-2/JH translocation in peripheral blood lymphocytes of unexposed individuals:: Lack of seasonal variations in frequency and molecular features
BCL-2/JH translocation in peripheral blood lymphocytes of unexposed individuals:: Lack of seasonal variations in frequency and molecular features
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DOI：
10.1002/ijc.10975
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发表时间：
2003-05-10
影响因子：
6.4
通讯作者：
Gauduchon, P
中科院分区：
文献类型：
--
作者：
Roulland, S;Lebailly, P;Gauduchon, P
BCL-2/J（H）重排被认为是评价职业和环境暴露遗传毒性的生物标志物。在未暴露的健康个体的外周血淋巴细胞的这种重排的时间相关的修改的现有数据是稀缺的。我们调查了33名未暴露于遗传毒素的成年人在两个季节性时间点（冬季和春季）的BCL-2/J（H）重排特征。BCL-2/J（H）重排检出率为79%（检出限为8.48 × 10 ~（-8）），其频率范围为< 1 ~ 40个/百万淋巴细胞，与年龄呈显著正相关（p = 0.04）。根据这2个时间点，没有观察到BCL-2/J（H）重排频率或包含该重排的克隆数量的显着变化。在该人群中没有发现与季节相关的环境因素对BCL-2/J（H）重排的频率或分子特征的明显影响，表明这不是一个混杂因素。(C)2003 Wiley-Liss，Inc.
BCL-2/J(H) rearrangement has been proposed as a biomarker for evaluating the genotoxicity of occupational and environmental exposures. Available data on time-related modification of this rearrangement in peripheral blood lymphocytes in unexposed healthy individuals is scarce. We investigated the characteristics of BCL-2/J(H) rearrangements in 33 adults unexposed to genotoxins at 2 seasonal time points: winter and spring. BCL-2/J(H) rearrangement was detected in 79% of individuals (detection limit = 8.48 x 10(-8) Its frequency ranged from < 1 to 40 translocations per millio lymphocytes with a significant (p = 0.04) positive correlation with age. No significant modifications of BCL-2/J(H) rearrangement frequency or in the number of clones harboring this rearrangement were observed according the 2 time points. No obvious influence of season-related environmental factors on frequency or molecular features of BCL-2/J(H) rearrangements was found in this population suggesting that this would not be a confounding factor. (C) 2003 Wiley-Liss, Inc.