Interpenetrating polymer network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid
Interpenetrating polymer network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid
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DOI：
10.1016/j.ijbiomac.2010.05.003
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发表时间：
2010-08-01
影响因子：
8.2
通讯作者：
Aminabhavi, Tejraj M.
中科院分区：
文献类型：
--
作者：
Angadi, Sudha C.;Manjeshwar, Lata S.;Aminabhavi, Tejraj M.
以壳聚糖（CS）和羟乙基纤维素（HEC）为原料，制备了粒径为66-82 μ m的戊二醛交联互穿聚合物网络（IPN）共混微球。采用X射线衍射（XRD）、差示扫描量热法（DSC）和热重分析（TGA）等方法对微球进行表征，考察药物在IPN中的均匀分布，并对IPN的热稳定性进行研究。傅里叶变换红外（FTIR）光谱被用来了解化学相互作用，并评估IPN结构。用扫描电子显微镜（SEM）观察了微球的形貌。载药微球以球形形状生产，包封率为50 - 66%。在pH 7.4缓冲溶液中测量的平衡溶胀以及在pH 1.2和7.4缓冲溶液中药物的体外释放表明药物释放对交联以及IPN基质的共混物组成的依赖性。(C)2010 Elsevier B.V.保留所有权利。
Glutaraldehyde crosslinked interpenetrating polymer network (IPN) blend microspheres of chitosan (CS) and hydroxyethyl cellulose (HEC) were prepared in the form of microspheres (66-82 mu m dia) and investigated for the controlled release (CR) of isoniazid (INH), an antituberculosis drug. Microspheres were characterized by X-ray diffraction (XRD) to study the uniform distribution of drug in the matrices, differential scanning calorimetry (DSC) and thermogravimetry (TGA) to study thermal stabilities of IPN blends. Fourier transform infrared (FTIR) spectroscopy was used to understand chemical interactions and to assess the IPN structure. Scanning electron microscopy (SEM) was employed to investigate the morphology of microspheres. Drug-loaded microspheres were produced in spherical shapes with encapsulation efficiency ranging from 50 to 66%. Equilibrium swelling measured in pH 7.4 buffer solution as well as in vitro release of drug in pH 1.2 and 7.4 buffer solutions indicated the dependence of drug release on crosslinking as well as blend composition of the IPN matrix. (C) 2010 Elsevier B.V. All rights reserved.