Long-Term Serial Aerobic Exercise Capacity and Hemodynamic Properties in Clinically and Hemodynamically Good, "Excellent", Fontan Survivors
Long-Term Serial Aerobic Exercise Capacity and Hemodynamic Properties in Clinically and Hemodynamically Good, "Excellent", Fontan Survivors
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DOI：
10.1253/circj.cj-11-0540
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发表时间：
2012-01-01
影响因子：
3.3
通讯作者：
Yamada, Osamu
中科院分区：
文献类型：
--
作者：
Ohuchi, Hideo;Ono, Shin;Yamada, Osamu
背景：长期、良好的 Fontan 幸存者的系列血流动力学和预测因素仍然未知。方法和结果：对 1998 年 9 月之前接受过 Fontan 手术的 201 名患者进行了回顾，以将他们的长期临床状态与系列血流动力学进行比较。在平均 18.7 年的随访期间，156 名幸存者中有 47 名（30.1%）没有出现需要计划外住院治疗的临床事件。其中18例存活者表现出良好的连续血流动力学，术前及术后1年、5年、10年、15年的中心静脉压（CVP，mmHg）、心脏指数（CI，L.min（-1）.m（-2））和心室射血分数（EF，%）平均值分别为：3.8、9.0、11.3、10.6和10.1（CVP）； 3.6、3.1、2.8、2.6、2.6 和 69 (CI)； 57、56、58、54 和 53 (EF)。良好患者的CVP、心室舒张末压（EDP）和房室瓣关闭不全（AVVR）等级的系列值较低，峰值摄氧量较高（P
Background: The serial hemodynamics and predictors of long-term, good Fontan survivors remain unknown.Methods and Results: Two hundred one patients who had undergone a Fontan operation before September 1998 were reviewed to compare their long-term clinical status with serial hemodynamics. During a mean follow-up of 18.7 years, 47 (30.1%) of the 156 survivors had no clinical events that required an unscheduled hospitalization. Of those, 18 survivors exhibited good serial hemodynamics and the respective mean values of central venous pressure (CVP, mmHg), cardiac index (CI, L.min(-1).m(-2)), and ventricular ejection fraction (EF, %) before and 1, 5, 10, and 15 years after the operation were as follows: 3.8, 9.0, 11.3, 10.6, and 10.1 (CVP); 3.6, 3.1, 2.8, 2.6, and 2.6, and 69 (CI); 57, 56, 58, 54, and 53 (EF). Serial values of CVP, ventricular end-diastolic pressure (EDP) and the grade of atrioventricular valve regurgitation (AVVR) were lower and the peak oxygen uptake was greater in the good patients (P