Ecological Populations of Bacteria Act as Socially Cohesive Units of Antibiotic Production and Resistance
Ecological Populations of Bacteria Act as Socially Cohesive Units of Antibiotic Production and Resistance
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DOI：
10.1126/science.1219385
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发表时间：
2012-09-07
期刊：
影响因子：
56.9
通讯作者：
Polz, Martin F.
中科院分区：
文献类型：
--
作者：
Cordero, Otto X.;Wildschutte, Hans;Polz, Martin F.
在动物和植物中，社会结构可以减少种群内部的冲突和对竞争种群的偏见攻击；然而，对于野外的细菌来说，是否存在这种种群水平的组织仍然是未知的。在这里，我们表明环境细菌被组织成社会凝聚力单位，其中拮抗发生在生态定义的种群之间，而不是在种群内。通过筛选来自海洋的弧菌科分离株之间大约35,000种可能的相互作用，我们发现已知具有内聚栖息地关联的基因型集群也作为抗生素生产和耐药性的单位。遗传分析表明，在种群内，少数基因型生产广谱抗生素，而所有其他基因型都具有耐药性，这表明同种异种之间存在合作。因此，天然抗生素可以调节种群之间的竞争，而不仅仅是增加个体的成功。
In animals and plants, social structure can reduce conflict within populations and bias aggression toward competing populations; however, for bacteria in the wild it remains unknown whether such population-level organization exists. Here, we show that environmental bacteria are organized into socially cohesive units in which antagonism occurs between rather than within ecologically defined populations. By screening approximately 35,000 possible mutual interactions among Vibrionaceae isolates from the ocean, we show that genotypic clusters known to have cohesive habitat association also act as units in terms of antibiotic production and resistance. Genetic analyses show that within populations, broad-range antibiotics are produced by few genotypes, whereas all others are resistant, suggesting cooperation between conspecifics. Natural antibiotics may thus mediate competition between populations rather than solely increase the success of individuals.