Numerical simulation of pulsatile flow in a compliant curved tube model of a coronary artery
Numerical simulation of pulsatile flow in a compliant curved tube model of a coronary artery
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DOI：
10.1115/1.429629
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发表时间：
2000-02-01
影响因子：
1.7
通讯作者：
Tarbell, JM
中科院分区：
文献类型：
--
作者：
Qiu, YC;Tarbell, JM
血管壁上的内皮细胞暴露在血流的壁切应力(WSS)和脉动动脉壁运动的周向应变(CS)下。这两种力量及其相互作用被认为在决定血管壁的重塑和动脉疾病(动脉粥样硬化)的发展中发挥作用。本研究重点研究了冠状动脉顺应性模型中WSS和CS的动态行为，其中考虑了弯曲动脉的曲率和生理性的径向室壁运动。建立了一个具有瞬变流动和运动边界的三维有限元模型，模拟了具有冠状动脉生理压力和流动波形特征的脉动流。模拟的冠脉曲率和流动特征条件为：长径比(Lambda)=10，内径变化量(Dv)=6%，平均雷诺数(Re)=150，非定常参数(α)=3。结果表明，内壁的平均WSS比外壁低约50%，而内壁的WSS振荡较强。CS和WSS之间的应力相角(SPA)表征了施加于内皮细胞层的机械力模式的动力学，表明CS和WSS在冠脉中比循环的任何其他区域更不同相(外壁-220度，内壁-250度)。提示除WSS外，SPA可能在冠状动脉粥样硬化的定位中发挥作用。[S0148-0731(00)01201-2]。
The endothelial cells (ECs) lining a blood vessel wall are exposed to both the wall shear stress (WSS) of blood flow and the circumferential strain (CS) of pulsing artery wall motion. These two forces and their interaction are believed to play a role in determining remodeling of the vessel wall and development of arterial disease (atherosclerosis). This study focused on the WSS and CS dynamic behavior in a compliant model of a coronary artery taking into account the curvature of the bending artery and physiological radial wall motion. A three-dimensional finite element model with transient flow and moving boundaries was set up to simulate pulsatile flow with physiological pressure and flow wave forms characteristic of the coronary arteries. The characteristic coronary artery curvature and flow conditions applied to the simulation were: aspect ration (lambda) = 10, diameter variation (DV) = 6 percent, mean Reynolds number (Re) = 150, and unsteadiness parameter (alpha) = 3. The result show that mean WSS is about 50 percent lower on the inside wall than the outside wall while WSS oscillation is stronger on the inside wall. The stress phase angle (SPA) between CS and WSS, which characterized the dynamics of the mechanical force pattern applied to the endothelial cell layer, shows that CS and WSS are more out of phase in the coronaries than in any other region of the circulation (-220 deg on the outside wall, -250 deg on the inside wall). The suggests that in addition to WSS, SPA may play a role in localization of coronary atherosclerosis. [S0148-0731(00)01201-2].