BIOMARKERS OF ENVIRONMENTAL TOBACCO-SMOKE IN PRESCHOOL-CHILDREN AND THEIR MOTHERS
BIOMARKERS OF ENVIRONMENTAL TOBACCO-SMOKE IN PRESCHOOL-CHILDREN AND THEIR MOTHERS
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DOI：
10.1093/jnci/86.18.1398
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发表时间：
1994-09-21
期刊：
影响因子：
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通讯作者：
PERERA, FP
中科院分区：
文献类型：
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作者：
CRAWFORD, FG;MAYER, J;PERERA, FP
背景：可归因于环境烟草烟雾(ETS)的不良健康影响包括非吸烟者的呼吸系统疾病和肺癌。越来越多的证据表明，由于儿童在发育早期接触致癌物质，他们在晚年患癌症的风险可能会增加。令人担忧的是，多达900万5岁以下的美国儿童可能接触ETS。目的：我们的目标是评估可替宁和多环芳烃白蛋白(PAH-白蛋白)水平是否与儿童和育龄妇女ETS暴露有关，在考虑了饮食、工作场所和家庭环境中多环芳烃白蛋白的背景暴露后。方法：研究队列由87名西班牙裔和非裔美国母亲及其87名学龄前儿童(2-5岁)组成。血浆可替宁采用气相色谱分析，外周血多环芳烃-白蛋白加合物采用酶联免疫吸附分析法检测。暴露数据通过访谈管理的问卷获得。结果：母亲吸烟的儿童的可替宁和多环芳烃白蛋白均显著高于非吸烟母亲的儿童(P
Background: Adverse health effects attributable to environmental tobacco smoke (ETS) include respiratory illness and lung cancer in nonsmokers. There is accumulating evidence that children may be at heightened risk of cancer later in life as a result of exposure to carcinogens during their early development. It is of concern that as many as 9 million American children under the age of 5 years may be exposed to ETS. Purpose: Our goal was to assess whether levels of cotinine and polycyclic aromatic hydrocarbon-albumin (PAH-albumin) are associated with ETS exposure in children and in women of reproductive age, after accounting for background exposures to PAHs in the diet, workplace, and the home environment. Methods: The study cohort was composed of 87 Hispanic and African-American mothers and 87 of their preschool children (2-5 years of age). Plasma cotinine was analyzed by gas chromatography; PAH-albumin adducts in peripheral blood were analyzed by enzyme-linked immunosorbent assay. Exposure data were obtained by interview-administered questionnaires. Results: Both cotinine and PAH-albumin were significantly higher in the children whose mothers smoked than in the children of nonsmoking mothers (P