Retroocular fibroblasts: important effector cells in Graves' ophthalmopathy.
Retroocular fibroblasts: important effector cells in Graves' ophthalmopathy.
复制标题
眼后成纤维细胞：格雷夫斯眼病的重要效应细胞。
DOI：
10.1089/thy.1992.2.89
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Heufelder,AE
中科院分区：
文献类型：
--
作者：
Bahn,RS;Heufelder,AE
眼后和胫前成纤维细胞可能是Graves眼病和胫前皮肤病的重要效应细胞。格雷夫斯病不同甲状腺外表现的组织之间存在组织学上的相似性。这两种情况的特点都是糖胺聚糖（GAGs）的积累和淋巴细胞的浸润。我们已经证明，可能由局部炎症细胞浸润释放的特定细胞因子能够刺激眼后和胫前成纤维细胞合成GAG。为了解释Graves病中这些解剖上不同的部位的选择性参与，我们试图确定眼后和胫前成纤维细胞共有的独特特征。我们已经证明，受影响的眼后和胫前成纤维细胞对干扰素- γ治疗表现出增强的HLA-DR反应，并且眼后成纤维细胞对这种细胞因子的gag刺激作用特别敏感。此外，我们已经表明，只有受影响的眼后和胫前成纤维细胞表达72 kDa的热休克蛋白。因此，受影响的眼后和胫前成纤维细胞具有独特的免疫特征，可能使它们更容易受到格雷夫斯病自身免疫过程的影响。局部炎症环境中释放的细胞因子对成纤维细胞的慢性刺激可能导致这些细胞产生过量的GAG。这些亲水性粘多糖的积累，伴随水肿，导致格雷夫斯眼病和胫前皮肤病的临床表现。
Retroocular and pretibial fibroblasts are likely important effector cells in Graves' ophthalmopathy and pretibial dermopathy. Histologic similarities exist between the tissues involved in these clinically diverse extrathyroidal manifestations of Graves' disease. Both conditions are characterized by an accumulation of glycosaminoglycans (GAGs) and an infiltration of lymphocytes. We have shown that particular cytokines, probably released by the local inflammatory cell infiltrate, are capable of stimulating GAG synthesis by retroocular and pretibial fibroblasts. In order to explain the site-selective involvement of these anatomically distinct areas in Graves' disease, we sought to identify unique characteristics shared by retroocular and pretibial fibroblasts. We have shown that affected retroocular and pretibial fibroblasts demonstrate an enhanced HLA-DR response to interferon-gamma treatment and that retroocular fibroblasts are especially sensitive to the GAG-stimulating effect of this cytokine. In addition, we have shown that only affected retroocular and pretibial fibroblasts express the 72 kDa heat shock protein. Therefore, affected retroocular and pretibial fibroblasts possess unique immunologic features that may render them more susceptible to the autoimmune process in Graves' disease. Chronic stimulation of fibroblasts by cytokines released in the local inflammatory milieu may result in excessive GAG production by these cells. The accumulation of these hydrophilic mucopolysaccharides, with attendant edema, leads to the clinical manifestations of Graves' ophthalmopathy and pretibial dermopathy.