The relationship between salivary secretory immunoglobulin A and cortisol: neuroendocrine response to awakening and the diurnal cycle
The relationship between salivary secretory immunoglobulin A and cortisol: neuroendocrine response to awakening and the diurnal cycle
复制标题
DOI：
10.1016/s0167-8760(98)00042-7
复制
发表时间：
1998-12-01
影响因子：
3
通讯作者：
Evans, P
中科院分区：
文献类型：
--
作者：
Hucklebridge, F;Clow, A;Evans, P
在慢性压力期间，唾液中测量的分泌性免疫球蛋白 A (sIgA) 水平会下调。相比之下，对急性压力挑战的反应是短暂的增加。觉醒过程与应激神经内分泌激活相关，其特征是唾液皮质醇增加。因此，我们检查了下丘脑-垂体-肾上腺 (HPA) 激活的这段时期是否与唾液 sIgA 的变化相关。另一项研究还调查了 sIgA 与昼夜皮质醇周期的关联。研究人员测量了 30 名每天活跃的健康年轻人的觉醒皮质醇反应。在接下来的 30 分钟内，与第一次觉醒水平相比，出现了明显的升高。 SIgA 表现出相反的反应，在同一时期的相同样本中，其首次觉醒的最高浓度显着下降。皮质醇升高与 sIgA 下降显着相关 (r = 0.42)。在一项针对八名健康年轻人的研究中，唾液 sIgA 显示出与皮质醇相似的昼夜周期。清晨出现顶峰期，醒来后约 6 小时下降至稳定的基础。讨论了这些关系的生理意义以及对感染脆弱性的可能影响。 (C) 1998 Elsevier Science B.V. 保留所有权利。
The level of secretory immunoglobulin A (sIgA) measured in saliva is downregulated during periods of chronic stress. In contrast, the response to an acute stress challenge is a transient increase. The process of awakening is associated with stress neuroendocrine activation characterised by increases in salivary cortisol. We therefore examined if this period of hypothalamic-pituitary-adrenal (HPA) activation was associated with changes in salivary sIgA. Associations of sIgA with the diurnal cortisol cycle were also investigated in a separate study. The awakening cortisol response was measured in 30 healthy day-active young adults. There was a marked elevation from the first awakening level over the succeeding 30 min. SIgA showed the opposite response with a marked fall from the highest first awakening concentration in the same samples over the same period. The cortisol rise was significantly correlated with the sIgA fall (r = 0.42). Salivary sIgA showed a similar diurnal cycle to cortisol in a study on eight healthy young adults. An early morning acrophase was followed by a decline to a stable base some 6 h after awakening. The physiological significance of these relationships and possible implications for vulnerability to infection are discussed. (C) 1998 Elsevier Science B.V. All rights reserved.