The neuropsychology of antisocial personality disorder
The neuropsychology of antisocial personality disorder
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DOI：
10.1017/s0033291702005378
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发表时间：
2002-04-01
影响因子：
6.9
通讯作者：
Park, I
中科院分区：
文献类型：
--
作者：
Dolan, M;Park, I
背景资料。由于诊断标准的差异和纳入健康对照对照组的差异，关于反社会人群执行功能的文献尚不清楚。一些研究表明，典型精神病与腹内侧额前叶(VMPFC)功能的特定缺陷有关，而不是与背外侧前额叶(DLPFC)有关。然而，元分析研究表明，反社会人格障碍可能与更广泛的管理缺陷有关。本研究分别使用剑桥神经心理测验自动化成套测验(CANTAB)和GO/NOGO任务评估反社会人格障碍受试者和对照组的DLPFC和VMPFC功能。所有受试者都接受了Axis I病理、药物滥用和处方药物的筛查。比较29例DSM-IV反社会人格障碍受试者和20例男性右利手对照(年龄和智商匹配)在神经心理测试中的表现。反社会人格障碍患者在DLPFC的执行功能、计划能力和定势转移任务上存在缺陷。VMPFC Go/NoGo任务和视觉记忆任务也存在损害。反社会性人格障碍与广泛的DLPFC和VMPFC功能缺陷有关。未来的研究需要检查反社会人格障碍的人际和行为成分与神经心理功能之间的关系。
Background. The literature on executive function in antisocial populations is unclear due to variation in diagnostic criteria and variation in the inclusion of healthy control comparison groups. Some studies suggest prototypical psychopathy is associated with specific deficits in ventromedial prefrontal (VMPFC) function rather than dorsolateral prefrontal (DLPFC). Meta-analytical studies, however, suggest that antisocial personality disorder may be associated with a broader range of executive deficits. This study assessed DLPFC and VMPFC function in antisocial personality disorder subjects and controls using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and a Go/NoGo task respectively.Methods. All subjects were screened for Axis I pathology, substance misuse and prescribed medication. The performance of 29 subjects with antisocial personality disorder DSM-IV and 20 male right-handed controls (matched for age and IQ) on the neuropsychological test battery was compared.Results. Subjects with antisocial personality disorder displayed impairments on DLPFC executive function tasks of planning ability and set shifting. Impairments were also seen in VMPFC Go/NoGo tasks and in visual memory tasks.Conclusions. Antisocial personality disorder is associated with a broad range of deficits in DLPFC and VMPFC function. Future studies need to examine relationships between the interpersonal and behavioural components of antisocial personality disorder and neuropsychological function.