The Emerging Roles of CCN3 Protein in Immune-Related Diseases.

The Emerging Roles of CCN3 Protein in Immune-Related Diseases.
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CCN3 蛋白在免疫相关疾病中的新作用

DOI:
10.1155/2021/5576059
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发表时间:
2021
影响因子:
4.6
通讯作者:
Duan L
Duan L
中科院分区:
医学3区
文献类型:
--
作者:
Peng L;Wei Y;Shao Y;Li Y;Liu N;Duan L

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CCN 蛋白是细胞外基质 (ECM) 相关蛋白家族,目前由六种分泌蛋白 (CCN1-6) 组成。 CCN3蛋白,也称为肾母细胞瘤过表达蛋白(NOV),是CCN家族的成员,具有多种生物学功能,参与细胞生长、迁移和分化等主要细胞过程。最近,CCN3 已成为多种疾病的关键调节因子,包括免疫相关疾病,包括风湿性关节炎、骨关节炎和系统性硬化症。本文将简要介绍CCN3蛋白的结构和功能,并总结CCN3在免疫相关疾病中的作用,这对于了解CCN3在免疫相关疾病中的功能至关重要。
The CCN proteins are a family of extracellular matrix- (ECM-) associated proteins which currently consist of six secreted proteins (CCN1-6). CCN3 protein, also known as nephroblastoma overexpressed protein (NOV), is a member of the CCN family with multiple biological functions, implicated in major cellular processes such as cell growth, migration, and differentiation. Recently, CCN3 has emerged as a critical regulator in a variety of diseases, including immune-related diseases, including rheumatology arthritis, osteoarthritis, and systemic sclerosis. In this review, we will briefly introduce the structure and function of the CCN3 protein and summarize the roles of CCN3 in immune-related diseases, which is essential to understand the functions of the CCN3 in immune-related diseases.
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