HEL CELLS - A NEW HUMAN ERYTHROLEUKEMIA CELL-LINE WITH SPONTANEOUS AND INDUCED GLOBIN EXPRESSION
HEL CELLS - A NEW HUMAN ERYTHROLEUKEMIA CELL-LINE WITH SPONTANEOUS AND INDUCED GLOBIN EXPRESSION
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DOI：
10.1126/science.6177045
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
PAPAYANNOPOULOU, T
中科院分区：
文献类型：
--
作者：
MARTIN, P;PAPAYANNOPOULOU, T
建立了一种新的人红细胞白血病细胞系。这个系被命名为HEL，能够自发和诱导地合成珠蛋白，主要产生g . γ。和A.gamma。链。胚胎链。， .zeta.)和。alpha。可以检测到非常少量的。β链。链条是检测不到的。该细胞系为研究红细胞分化和差异珠蛋白基因表达等方面提供了新的模型系统。
A new human erythroleukemia cell line was established. This line, designated HEL, is capable of spontaneous and induced globin synthesis, producing mainly G.gamma. and A.gamma. chains. Embryonic chains (.epsilon., .zeta.) and .alpha. chains are detectable in very small amounts: .beta. chains are undetectable. This line provides a new model system for studying aspects of erythroid cell differentiation and differential globin gene expression.