Mechanisms of integrin activation and trafficking
Mechanisms of integrin activation and trafficking
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DOI：
10.1016/j.ceb.2011.08.005
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发表时间：
2011-10-01
影响因子：
7.5
通讯作者：
Sonnenberg, Arnoud
中科院分区：
文献类型：
--
作者：
Margadant, Coert;Monsuur, Hanneke N.;Sonnenberg, Arnoud
整联蛋白粘附受体对于大多数多细胞生物体的正常功能是必需的，并且有缺陷的整联蛋白活化或整联蛋白信号传导与一系列病理状况相关。整合素受构象变化、聚集和运输的调节，并且调节机制在个体整合素之间和细胞类型之间有很大差异。尽管循环血细胞中的整联蛋白通过由内而外诱导的有利于高亲和力配体结合的构象变化来激活，但粘附细胞中的β 1-整联蛋白可以通过力或聚集来激活。此外，内吞和再循环在粘附细胞中整合素周转和整合素再分布的调节中起重要作用，特别是在动态过程如细胞迁移和侵袭期间。整合素的运输受到其胞质尾区的强烈调控，其机制目前正在研究中。
Integrin adhesion receptors are essential for the normal function of most multicellular organisms, and defective integrin activation or integrin signaling is associated with an array of pathological conditions. Integrins are regulated by conformational changes, clustering, and trafficking, and regulatory mechanisms differ strongly between individual integrins and between cell types. Whereas integrins in circulating blood cells are activated by an inside-out-induced conformational change that favors high-affinity ligand binding, beta 1-integrins in adherent cells can be activated by force or clustering. In addition, endocytosis and recycling play an important role in the regulation of integrin turnover and integrin redistribution in adherent cells, especially during dynamic processes such as cell migration and invasion. Integrin trafficking is strongly regulated by their cytoplasmic tails, and the mechanisms are now being identified.