Oral Dysfunction in Patients with Oral Cancer Could Occur Before Treatment and Require Early Nutritional Improvement: A Cross-Sectional Study
Oral Dysfunction in Patients with Oral Cancer Could Occur Before Treatment and Require Early Nutritional Improvement: A Cross-Sectional Study
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DOI：
10.1007/s00455-022-10531-4
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发表时间：
2022-10-15
期刊：
影响因子：
2.6
通讯作者：
Kanno, Takahiro
中科院分区：
文献类型：
--
作者：
Matsuda, Yuhei;Okui, Tatsuo;Kanno, Takahiro
口腔癌患者在治疗前营养状况较差。然而，目前还没有详细的评估术前口腔功能的口腔鳞状细胞癌（OSCC）患者的报告。因此，本研究旨在评估口腔鳞状细胞癌患者术前的口腔功能，并探讨其与营养状况的关系。口腔功能测量收集51例OSCC患者的口腔微生物、口腔干燥、咬合力、舌压、咀嚼功能、进食评估工具和术后口腔功能障碍量表的数据和简易营养评估简表（MNA-SF（男性：37，女性：14，平均年龄：72.1岁），于2019年9月至2021年9月在岛根大学附属医院口腔颌面外科就诊。舌是最常见的原发性牙龈部位[22例患者（43.1%）]，36例患者（70.6%）患有晚期癌症。营养状况和每个相关因素之间的比较显示，家庭中的个人数量、癌症分期、肺部疾病的存在、牙齿数量、微生物（等级）和咀嚼功能（mg/dL）存在显著差异（p < 0.05）。以MNA-SF总分为因变量，调整混杂因素的多元回归分析显示口干与舌压之间存在显著相关性（p < 0.05）。进食评估工具或术后口腔功能障碍量表无显著相关性。口腔鳞状细胞癌患者在诊断时可能因为肿瘤而导致口腔功能下降，从而导致营养状况下降。术前干预是必要的，以改善营养的基础上，口腔功能的状态。
Patients with oral cancer have poor nutritional status before treatment. However, there have been no reports of the detailed evaluation of preoperative oral function in patients with oral squamous cell carcinoma (OSCC). Therefore, this study aimed to evaluate the preoperative oral function of patients with OSCC and examine the relationship with nutritional status. Oral function measurements (microorganisms, oral dryness, occlusal force, tongue pressure, masticatory function, Eating Assessment Tool, and Postoperative Oral Dysfunction Scale) and Mini Nutritional Assessment-Short Form (MNA-SF) data were collected from 51 patients with OSCC (men: 37, women: 14, mean age: 72.1 years) who visited the Shimane University Hospital, Department of Oral and Maxillofacial Surgery, from September 2019 to September 2021. The tongue was the most prevalent primary gingiva site [22 patients (43.1%)], and 36 patients (70.6%) had advanced cancer. Comparisons between nutritional status and each related factor revealed significant differences in the number of individuals in the household, cancer stage, presence of pulmonary disease, number of teeth, microorganisms (grade), and masticatory function (mg/dL) (p < 0.05). Multiple regression analysis using the total MNA-SF score as the dependent variable with adjustment for confounding factors showed significant association between oral dryness and tongue pressure (p < 0.05). No significant association was found for the Eating Assessment Tool or Postoperative Oral Dysfunction scale. Patients with OSCC may have decreased oral function because of the tumor at the time of diagnosis, which causes a decline in nutritional status. Preoperative interventions are necessary to improve nutrition based on the state of oral function.