SUSCEPTIBILITY OF DOGS TO WEST NILE VIRUS - A SURVEY AND PATHOGENICITY TRIAL
SUSCEPTIBILITY OF DOGS TO WEST NILE VIRUS - A SURVEY AND PATHOGENICITY TRIAL
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DOI：
10.1016/0021-9975(89)90090-x
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发表时间：
1989-01-01
影响因子：
0.8
通讯作者：
SHEPHERD, AJ
中科院分区：
文献类型：
--
作者：
BLACKBURN, NK;REYERS, F;SHEPHERD, AJ
对南非高地地区的狗进行的一项血清学调查显示，37%(377只狗中的138只)有西尼罗河病毒中和抗体，只有2.7%(377只狗中的10只)有辛德比斯病毒的抗体。从一份WN抗体阴性的血清中分离到WN病毒。由于这些结果表明，狗可能在WN病毒的流行病学中发挥重要作用，因此进行了致病性试验。感染WN病毒的三只狗中有两只有轻度复发性肌病。感染WN病毒的三只狗中有两只有轻微的复发性肌病，但在对任何一只狗进行的生化或血液学测试中都没有发现其他异常。三只狗都产生了抗体，但只有一只狗检测到了低滴度病毒血症。结论是，狗在WN病毒的流行病学中不起重要作用，但它们可能在病毒的维持中起到很小的作用。
A serological survey of dogs from the highveld region of South Africa showed that 37 per cent (138 of 377) had neutralizing antibodies to West Nile (WN) virus and only 2.7 per cent (10 of 377) had antibodies to Sindbis virus. WN virus was isolated from one of the WN-antibody negative sera. Because these results suggested that dogs may play an important part in the epidemiology of WN virus, a pathogenicity trial was carried out. Two of three dogs infected with WN virus had a mild recurrent myopathy. Two of three dogs infected with WN virus had a mild recurrent myopathy, but no other abnormalities were detected in the biochemical or haematological tests performed on any of the dogs. All three dogs developed antibodies but a low titre-viraemia was detected in only one dog. It was concluded that dogs do not play an important part in the epidemiology of WN virus but they may play a small part in the maintenance of the virus.