UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species
UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species
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DOI：
10.1021/ol026923b
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发表时间：
2002-12-12
期刊：
影响因子：
5.2
通讯作者：
Kanda, Y
中科院分区：
文献类型：
--
作者：
Agatsuma, T;Akama, T;Kanda, Y
[图表] UCS 1025 A和B，具有前所未有的呋喃并吡咯里西啶骨架的新型五环聚酮化合物，从真菌枝顶孢属KY 4917中分离得到。通过二维核磁共振和X-射线晶体学分析的组合，阐明了结构和立体化学。UCS 1025 A显示出独特的化学平衡，涉及三种互变异构体，并对人肿瘤细胞系表现出抗微生物活性和抗增殖活性。
[GRAPHICS]UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were isolated from the fungus Acremonium sp. KY4917. The structures and stereochemistry were elucidated by a combination of two-dimensional NMR and X-ray crystallographic analysis. UCS1025A showed unique chemical equilibria involving three tautomeric isomers and exhibited antimicrobial activity and anti proliferative activity against human tumor cell lines.