Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination.
Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination.
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DOI：
10.1016/j.gene.2012.08.021
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发表时间：
2012-11-15
期刊：
影响因子：
3.5
通讯作者：
Poland GA
中科院分区：
文献类型：
--
作者：
Ovsyannikova IG;Haralambieva IH;Kennedy RB;Pankratz VS;Vierkant RA;Jacobson RM;Poland GA
我们探索了细胞因子/细胞因子受体基因中的SNPs与初次接种天花疫苗受试者的细胞免疫之间的关系。我们还分析了在一群非裔美国人中高加索受试者中发现的基因-表型关联。在高加索人中，我们发现基因SNP与干扰素-α、IL-12p40、IL-1β、IL-2和肿瘤坏死因子-α分泌水平的个体间差异有关(p<；0.05)。IL1RN、IL2RB、IL4R、IL6、IL10RB、IL12A和IL12RB2基因的SNP集合在高加索人和非裔美国人中具有一致的相关性。在两个种族中，IL1RN基因的调节性SNP(Rs452204)以等位基因剂量依赖的方式与较高水平的IL-2分泌显著相关(p=0.002，对于高加索人)。IL12RB2基因多态性rs3790567与IL-1β分泌呈剂量相关性下降(高加索人p=0.009，非裔美国人p=0.01)。我们的结果表明，天花疫苗诱导的细胞因子反应的变化是由细胞因子和细胞因子受体基因的遗传多态调节的。
We explored associations between SNPs in cytokine/cytokine receptor genes and cellular immunity in subjects following primary smallpox vaccination. We also analyzed the genotype-phenotype associations discovered in the Caucasian subjects among a cohort of African-Americans. In Caucasians we found 277 associations (p<0.05) between gene SNPs and inter-individual variations in IFN-α, IL-12p40, IL-1β, IL-2, and TNF-α secretion levels. A collection of SNPs in the IL1RN, IL2RB, IL4R, IL6, IL10RB, IL12A, and IL12RB2 genes had consistent associations among both Caucasians and African-Americans. A regulatory SNP (rs452204) in the IL1RN gene was significantly associated with higher levels of IL-2 secretion in an allele dose-dependent manner in both race groups (p=0.05 for Caucasians and p=0.002 for African-Americans). IL12RB2 polymorphism rs3790567 was associated with a dose-related decrease in IL-1β secretion (p=0.009 for Caucasians and p=0.01 for African-Americans). Our results demonstrate that variations in smallpox vaccine-induced cytokine responses are modulated by genetic polymorphisms in cytokine and cytokine receptor genes.
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DOI：
10.1158/1055-9965.epi-07-2753
发表时间：
2008-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
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作者：
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通讯作者：
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影响因子：
5.5
作者：
Haralambieva, Iana H.;Ovsyannikova, Inna G.;Kennedy, Richard B.;Vierkant, Robert A.;Pankratz, V. Shane;Jacobson, Robert M.;Poland, Gregory A.
通讯作者：
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影响因子：
5
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
6.4
作者：
Ovsyannikova, Inna G.;Vierkant, Robert A.;Poland, Gregory A.
通讯作者：
Poland, Gregory A.