Cross-couplings of unactivated secondary alkyl halides: Room-temperature nickel-catalyzed Negishi reactions of alkyl bromides and iodides
Cross-couplings of unactivated secondary alkyl halides: Room-temperature nickel-catalyzed Negishi reactions of alkyl bromides and iodides
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DOI：
10.1021/ja0389366
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发表时间：
2003-12-03
影响因子：
15
通讯作者：
Fu, GC
中科院分区：
文献类型：
--
作者：
Zhou, JR;Fu, GC
开发用于交叉偶联未活化的仲烷基卤化物的镍或钯催化方法一直是合成化学中的长期挑战。本文描述了一种简单的催化剂体系-Ni（cod）2/s-Bu-Pybox-，它能实现一系列官能化伯、仲烷基溴和碘的室温Negishi反应。
The development of a nickel- or palladium-catalyzed method for cross-coupling unactivated secondary alkyl halides has been a long-standing challenge in synthetic chemistry. This communication describes a simple catalyst system-Ni(cod)2/s-Bu-Pybox-that achieves room-temperature Negishi reactions of an array of functionalized primary and secondary alkyl bromides and iodides.