THE EFFECT OF CA-2+-ANTAGONIST ON VISUAL-FIELD IN LOW-TENSION GLAUCOMA
THE EFFECT OF CA-2+-ANTAGONIST ON VISUAL-FIELD IN LOW-TENSION GLAUCOMA
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DOI：
10.1007/bf02172889
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发表时间：
1989-01-01
影响因子：
2.7
通讯作者：
GO, FJ
中科院分区：
文献类型：
--
作者：
KITAZAWA, Y;SHIRAI, H;GO, FJ
本研究采用前瞻性研究方法，探讨钙拮抗剂对低眼压性青光眼（LTG）视野的影响。25例（50眼）LTG患者口服硝苯地平30 mg/d，疗程6个月。在硝苯地平给药前和给药期间每月用Octopus 201（程序G1）测试视野。除了眼压测量和全身血压和脉搏率的测量之外，通过确定手指的皮肤温度对冷水（4 ° C）的响应来估计外周血管的反应性。C）。12只眼（6例患者）表现出视野的持续改善，表现为平均灵敏度（MS）的增加。典型判别分析表明，视野是可能改善与全身硝苯地平的患者是年轻的，有较高的初始MS和较低的眼内压，并有较小的降低舒张压与硝苯地平管理和更好的冷恢复皮肤温度后，他们的手浸泡在冷水中。
A prospective study was conducted to evaluate the effects of Ca2+-antagonist on the visual field in low-tension glaucoma (LTG). Twenty-five consecutive patients (50 eyes) with LTG received nifedipine at 30 mg/day per os for 6 months. Visual field was tested with an Octopus 201 (program G1) prior to and each month during the period of nifedipine administration. In addition to tonometry and the measurements of systemic blood pressure and pulse rate, the reactivity of peripheral vessels was estimated by determining the response of skin temperature of a finger to cold water (4.degree. C). Twelve eyes (six patients) showed a constant improvement of visual field as expressed by an increase in mean sensitivity (MS). Canonical discriminant analysis demonstrated that the visual field is likely to improve with systemic nifedipine in patients who are young, have a higher initial MS and lower intraocular pressure, and have less decrease in diastolic blood pressure with the nifedipine administration and better cold recovery of skin temperature after their hand is soaked in cold water.