Do the different parental 'heteromes' cause genomic shock in newly formed allopolyploids?
Do the different parental 'heteromes' cause genomic shock in newly formed allopolyploids?
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DOI：
10.1098/rstb.2003.1305
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发表时间：
2003-06-29
影响因子：
6.3
通讯作者：
Tyagi, A
中科院分区：
文献类型：
--
作者：
Comai, L;Madlung, A;Tyagi, A
异源多倍性是指在二倍体减数分裂过程中，两个亲本基因组的结合，是网状进化的一种重要机制。虽然许多成功的长期建立的异源多倍体是已知的，那些最近形成的经历了一个不稳定的阶段，其基础现在正在表征。我们描述了与拟南芥系统，包括表型不稳定性，基因沉默和激活，甲基化的变化所作的观察。我们提出了一个模型的基础上的表观遗传不稳定的基因组重复，这在父母heterochromatinized和抑制。我们假设，这些序列的表观遗传抑制的损失，在这里定义为异基因组，导致基因组的不稳定性，包括单拷贝基因的沉默。
Allopolyploidy, the joining of two parental genomes in a polyploid organism with diploid meiosis, is an important mechanism of reticulate evolution. While many successful long-established allopolyploids are known, those formed recently undergo an instability phase whose basis is now being characterized. We describe observations made with the Arabidopsis system that include phenotypic instability, gene silencing and activation, and methylation changes. We present a model based on the epigenetic destabilization of genomic repeats, which in the parents are heterochromatinized and suppressed. We hypothesize that loss of epigenetic suppression of these sequences, here defined as the heterome, results in genomic instability including silencing of single-copy genes.