A framework for microbiome science in public health
A framework for microbiome science in public health
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DOI：
10.1038/s41591-021-01258-0
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发表时间：
2021-04-05
期刊：
影响因子：
82.9
通讯作者：
Huttenhower, Curtis
中科院分区：
文献类型：
--
作者：
Wilkinson, Jeremy E.;Franzosa, Eric A.;Huttenhower, Curtis
微生物组科学正在快速发展，本视角详细介绍了其与公共卫生的精心融合。人类微生物组科学发展迅速，达到了基础生物学、临床转化和人口健康日益融合的规模。因此，公共卫生研究人员、从业人员和政策制定者现在可以利用当前和未来基于微生物组的机会和最佳实践采取具体行动。在这里，我们概述了有关人类微生物组和公共卫生的研究、教育、解释和科学传播的考虑因素。这包括人口规模微生物组研究设计指南；必要的物理平台和分析方法；融入流行病学、营养、慢性病以及全球和环境健康等公共卫生领域；创业和技术转让；和教育课程。特别是在不久的将来，不仅有机会将基于微生物组的技术纳入公共卫生实践，而且对益生元和益生菌补充剂、新型活细胞疗法和粪便微生物群移植等相关领域的政策制定和监管的需求也日益增长。
Microbiome science is fast advancing and its careful integration into public health is detailed in this Perspective.Human microbiome science has advanced rapidly and reached a scale at which basic biology, clinical translation and population health are increasingly integrated. It is thus now possible for public health researchers, practitioners and policymakers to take specific action leveraging current and future microbiome-based opportunities and best practices. Here we provide an outline of considerations for research, education, interpretation and scientific communication concerning the human microbiome and public health. This includes guidelines for population-scale microbiome study design; necessary physical platforms and analysis methods; integration into public health areas such as epidemiology, nutrition, chronic disease, and global and environmental health; entrepreneurship and technology transfer; and educational curricula. Particularly in the near future, there are both opportunities for the incorporation of microbiome-based technologies into public health practice, and a growing need for policymaking and regulation around related areas such as prebiotic and probiotic supplements, novel live-cell therapies and fecal microbiota transplants.