Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability
Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability
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DOI：
10.1177/1352458511404916
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发表时间：
2011-09-01
影响因子：
5.8
通讯作者：
Geurts, Jeroen J. G.
中科院分区：
文献类型：
--
作者：
Roosendaal, Stefan D.;Bendfeldt, Kerstin;Geurts, Jeroen J. G.
背景：虽然目前已经认识到多发性硬化症中的灰质损伤，但灰质体积的决定因素及其与残疾的关系尚不清楚。目的：本研究的目的是测量不同疾病表型的灰质和白质体积；确定与灰质体积相关的MRI参数；并研究灰质和白质体积作为临床损伤的解释变量。方法：这是一项横断面研究，收集了来自三个中心的95例临床孤立综合征、657例复发缓解型、125例继发性进展型和50例原发性进展型多发性硬化症患者的MRI数据。测定灰质和白质体积以及T2和T1病变体积。身体残疾用扩展残疾状态量表评估，认知障碍用节奏性听觉序列加法任务评估。数据采用多元回归分析。结果：复发缓解型患者灰质体积（平均[SD]: 0.80 [0.05] L）低于临床孤立综合征患者（0.82 [0.05]L），继发性进展型患者灰质体积相对萎缩更大（0.77 [0.05]L）。相比之下，继发性进展患者的白质体积与复发缓解患者相当。灰质体积是身体残疾和认知障碍的最强独立预测因子，并且与T2和T1病变体积相关。结论：我们的研究结果表明，与复发缓解型疾病相比，继发性进展性疾病的灰质体积更小。灰质体积比白质体积更能解释身体和认知障碍，并且灰质体积本身与T2和T1病变体积有关。
Background: Although grey matter damage in multiple sclerosis is currently recognized, determinants of grey matter volume and its relationship with disability are not yet clear.Objectives: The objectives of the study were to measure grey and white matter volumes across different disease phenotypes; identify MRI parameters associated with grey matter volume; and study grey and white matter volume as explanatory variables for clinical impairment.Methods: This is a cross-sectional study in which MRI data of 95 clinically isolated syndrome, 657 relapsing-remitting, 125 secondary-progressive and 50 primary-progressive multiple sclerosis patients from three centres were acquired. Grey and white matter volumes were determined, together with T2 and T1 lesion volumes. Physical disability was assessed with the Expanded Disability Status Scale, cognitive impairment with the Paced Auditory Serial Addition Task. Data were analysed using multiple regression.Results: Grey matter volume was lower in relapsing-remitting patients (mean [SD]: 0.80 [0.05] L) than in clinically isolated syndrome patients (0.82 [0.05] L), and even greater relative atrophy was found in secondary-progressive patients (0.77 [0.05] L). In contrast, white matter volume in secondary-progressive patients was comparable to that in relapsing-remitting patients. Grey matter volume was the strongest independent predictor of physical disability and cognitive impairment, and was associated with both T2 and T1 lesion volume.Conclusions: Our findings show that grey matter volume is lower in secondary-progressive than in relapsing-remitting disease. Grey matter volume explained physical and cognitive impairment better than white matter volume, and is itself associated with T2 and T1 lesion volume.