T2-based MRI Delta-radiomics improve response prediction in soft-tissue sarcomas treated by neoadjuvant chemotherapy.
T2-based MRI Delta-radiomics improve response prediction in soft-tissue sarcomas treated by neoadjuvant chemotherapy.
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DOI：
10.1002/jmri.26589
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发表时间：
2019-08-01
影响因子：
4.4
通讯作者：
Saut, Olivier
中科院分区：
文献类型：
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作者：
Crombe, Amandine;Perier, Cynthia;Saut, Olivier
背景随着新辅助化疗(NAC)对患者预后的积极影响，高度恶性软组织肉瘤(STS)患者的护理标准正在被重新定义。然而，临床试验中的反应评估仍然依赖于RECIST标准。目的探讨Delta放射组学方法对接受NAC治疗的STS患者的早期疗效预测的附加值。研究类型回顾。人群65例新诊断的、局部晚期的、经组织学证实的躯干和四肢高级别STS的成人患者。所有患者均在手术后接受了以蒽环类药物为基础的NAC治疗，并在基线和两个化疗周期后进行了有效的MRI检查。增强前后的场强/序列增强T-1加权成像(T-1-W I)，1.5T的快速自旋回波T-2-W I
Background Standard of care for patients with high-grade soft-tissue sarcoma (STS) are being redefined since neoadjuvant chemotherapy (NAC) has demonstrated a positive effect on patients' outcome. Yet response evaluation in clinical trials still relies on RECIST criteria. Purpose To investigate the added value of a Delta-radiomics approach for early response prediction in patients with STS undergoing NAC. Study Type Retrospective. Population Sixty-five adult patients with newly-diagnosed, locally-advanced, histologically proven high-grade STS of trunk and extremities. All were treated by anthracycline-based NAC followed by surgery and had available MRI at baseline and after two chemotherapy cycles. Field Strength/Sequence Pre- and postcontrast enhanced T-1-weighted imaging (T-1-WI), turbo spin echo T-2-WI at 1.5 T. Assessment A threshold of