Emerging roles of sumoylation in the regulation of actin, microtubules, intermediate filaments, and septins.
Emerging roles of sumoylation in the regulation of actin, microtubules, intermediate filaments, and septins.
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DOI：
10.1002/cm.21226
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发表时间：
2015-07
期刊：
影响因子：
2.9
通讯作者：
Miller, Rita K.
中科院分区：
文献类型：
--
作者：
Alonso, Annabel;Greenlee, Matt;Matts, Jessica;Kline, Jake;Davis, Kayla J.;Miller, Rita K.
Sumoylation是一个强大的调控系统，控制着细胞中的许多关键过程，包括DNA修复、转录调控、核转运和DNA复制。最近，相扑的新功能开始出现。SUMO共价附着于四种主要细胞骨架网络的组成部分，包括微管相关蛋白、septin和中间丝，以及核肌动蛋白和肌动蛋白调节蛋白。然而，这种信号转导系统控制细胞骨架的机制的知识仍处于起步阶段。一个开始展开的故事是，SUMO可能通过修饰其适配器Lis1来调节微管运动蛋白动力蛋白。在其他情况下，细胞骨架元件既可以与SUMO非共价结合，也可以被SUMO偶联。许多这些新功能的分子机制尚不清楚，但正在积极研究中。一种新出现的模型将MAP summoylation的功能与通过SUMO靶向泛素连接酶（也称为STUbL酶）的蛋白质降解联系起来。还讨论了细胞骨架聚合化的其他可能功能。©2015作者。Wiley期刊公司出版的《细胞骨架》。
Sumoylation is a powerful regulatory system that controls many of the critical processes in the cell, including DNA repair, transcriptional regulation, nuclear transport, and DNA replication. Recently, new functions for SUMO have begun to emerge. SUMO is covalently attached to components of each of the four major cytoskeletal networks, including microtubule‐associated proteins, septins, and intermediate filaments, in addition to nuclear actin and actin‐regulatory proteins. However, knowledge of the mechanisms by which this signal transduction system controls the cytoskeleton is still in its infancy. One story that is beginning to unfold is that SUMO may regulate the microtubule motor protein dynein by modification of its adaptor Lis1. In other instances, cytoskeletal elements can both bind to SUMO non‐covalently and also be conjugated by it. The molecular mechanisms for many of these new functions are not yet clear, but are under active investigation. One emerging model links the function of MAP sumoylation to protein degradation through SUMO‐targeted ubiquitin ligases, also known as STUbL enzymes. Other possible functions for cytoskeletal sumoylation are also discussed. © 2015 The Authors. Cytoskeleton Published by Wiley Periodicals, Inc.
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影响因子：
4
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1083/jcb.123.6.1671
发表时间：
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期刊：
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影响因子：
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