LONG-TERM SENSITIZATION IN APLYSIA INCREASES THE NUMBER OF PRESYNAPTIC CONTACTS ONTO THE IDENTIFIED GILL MOTOR NEURON L7
LONG-TERM SENSITIZATION IN APLYSIA INCREASES THE NUMBER OF PRESYNAPTIC CONTACTS ONTO THE IDENTIFIED GILL MOTOR NEURON L7
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DOI：
10.1073/pnas.85.23.9356
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发表时间：
1988-12-01
影响因子：
11.1
通讯作者：
CHEN, M
中科院分区：
文献类型：
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作者：
BAILEY, CH;CHEN, M
我们已经使用鳃和虹吸回缩反射的Aaprissia研究的持续突触可塑性的形态学基础，长期敏化。存储敏化记忆的一个关键位点是已识别的虹吸感觉神经元与鳃和虹吸运动神经元之间的单突触连接。为了补充以前的形态学研究确定的感觉神经元的突触前末梢，我们研究了长期敏化的影响，确定的突触后目标的结构。sbd。鳃运动神经元L7。我们发现增加的频率，大小和囊泡补充突触前接触到L7过程中致敏相比，对照组动物。结合起来，这些数据表明，在长期训练后，突触接触所占据的L7表面积的百分比显著增加。这些结果与我们的观察结果一致，即致敏会导致感觉神经元在其靶细胞上形成的突触增加，并为突触数量变化可能代表长期记忆潜在机制的假设提供了额外的支持。
We have used the gill and siphon withdrawal reflex of Aplysia to study the morphological basis of the persistent synaptic plasticity that underlies long-term sensitization. One critical locus for storage of the memory for sensitization is the set of monosynaptic connections between identified siphon sensory neurons and gill and siphon motor neurons. To complement previous morphological studies of the presynaptic terminals of identified sensory neurons, we examined the effects of long-term sensitization on the structure of an identified postsynaptic target.sbd.the gill motor neuron L7. We found an increase in the frequency, size, and vesicle complement of presynaptic contacts onto L7 processes in sensitized compared to control animals. Combined, these data indicate a striking increase in the percentage of the surface area of L7 that is occupied by synaptic contacts after long-term training. These results are consistent with our observations that sensitization produces an increase in the synapses that the sensory neurons make on their target cells and provide additional support for the hypothesis that changes in synapse number may represent a mechanism underlying long-term memory.