In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study
In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study
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体内 [18F]THK-5351 成像检测到伴有共病病理的嗜银颗粒病中的反应性星形胶质细胞增生：临床病理学研究
DOI：
10.1093/jnen/nlad018
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Nobuyuki Okamura
中科院分区：
文献类型：
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作者：
Ryota Kobayashi ;Tadaho Nakamura;Fumito Naganuma;Ryuichi Harada;Daichi Morioka;Masafumi Kanoto;Shozo Furumoto;Yukitsuka Kudo;Takanobu Kabasawa;Koichi Otani;Mitsuru Futakuchi ;Shinobu Kawakatsu;Nobuyuki Okamura
体内反应性星形胶质细胞增生的定量，这代表了神经炎症和重塑的大脑，是一种新兴的方法，用于评估患者的神经退行性疾病。[18 F]THK-5351是单胺氧化酶B（MAO-B）的正电子发射断层扫描（PET）示踪剂，MAO-B是反应性星形胶质细胞增生的分子标志物。我们在尸检时发现患有嗜银颗粒病（AGD）并伴有共病病理的患者中进行了体内[18 F]THK-5351 PET，以首次可视化反应性星形胶质细胞增生。我们的目的是使用[18 F]THK-5351 PET和尸检大脑验证成像-病理学相关性。患者为78岁男性，病理诊断为AGD合并边缘型年龄相关性反式反应DNA结合蛋白43 kDa脑病和路易体病，无阿尔茨海默病相关神经病理改变。死后大脑中的反应性星形胶质细胞增生在颞下回、岛回、内嗅皮质和周围回中丰富，其中死后[18F]THK-5351信号高。我们发现死后脑中反应性星形胶质细胞增生的量与体内[18F]THK-5351标准化摄取值比率之间存在比例相关性（r= 0.8535，p = 0.0004）。这些结果表明，反应性星形胶质细胞增生AGD与共病病理可以确定和量化的体内MAO-B成像。
Quantification of in vivo reactive astrogliosis, which represents neural inflammation and remodeling in the brain, is an emerging methodology for the evaluation of patients with neurodegenerative diseases. [18F]THK-5351 is a positron emission tomography (PET) tracer for monoamine oxidase B (MAO-B), a molecular marker of reactive astrogliosis. We performed in vivo [18F]THK-5351 PET in a patient who at autopsy was found to have argyrophilic grain disease (AGD) with comorbid pathology to visualize reactive astrogliosis for the first time. We aimed to validate an imaging-pathology correlation using [18F]THK-5351 PET and the autopsy brain. The patient, a 78-year-old man, was pathologically diagnosed with AGD combined with limbic-predominant age-related transactive response DNA-binding protein of 43 kDa encephalopathy and Lewy body disease without Alzheimer disease-related neuropathological changes. Reactive astrogliosis in the postmortem brain was abundant in the inferior temporal gyrus, insular gyrus, entorhinal cortex, and ambient gyrus where premortem [18F]THK-5351 signals were high. We found a proportional correlation between the amount of reactive astrogliosis in the postmortem brain and the in vivo [18F]THK-5351 standardized uptake value ratio (r= 0.8535, p = 0.0004). These results indicated that reactive astrogliosis in AGD with comorbid pathology could be identified and quantified by in vivo MAO-B imaging.