The impact of asthma on COVID-19 disease severity in children and adolescents.
The impact of asthma on COVID-19 disease severity in children and adolescents.
复制标题
哮喘对儿童和青少年 COVID-19 疾病严重程度的影响。
DOI：
10.1080/02770903.2022.2132956
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
James,Pushpom
中科院分区：
文献类型：
--
作者：
Robbins,Emily;Daoud,Steven;Demissie,Seleshi;James,Pushpom
研究发现，哮喘和过敏性哮喘对成人预防冠状病毒病（COVID-19）有保护作用，但尚未对儿童进行研究。目的了解患有哮喘的儿童和青少年是否比没有哮喘的儿童和青少年患COVID-19的严重程度和发病率更低。方法回顾性分析2020年3月1日至2021年1月31日的病例。如果患者年龄在6岁以上，年龄在20岁以下，并且经PCR或抗原检测呈COVID-19阳性，或者在急诊科（ED）就诊时呈COVID-19抗体阳性，则符合纳入图表的条件。患者根据疾病严重程度分组，分为两组，哮喘组和无哮喘组。共纳入1585例患者，其中1492例无哮喘，93例有哮喘。结果患有哮喘的儿童和青少年因COVID-19相关疾病到急诊科就诊的可能性较低（p值< 0.0001），但如果到急诊科就诊，其住院、需要吸氧的可能性显著高于未患哮喘的儿童和青少年（p值< 0.0001）。结论患有哮喘的儿童和青少年虽然在患有COVID-19的急诊科不太可能被发现，但一旦出现在急诊科，他们比没有哮喘的患者更有可能出现严重的疾病。
BackgroundAtopy and allergic asthma have been found to be protective against coronavirus disease (COVID-19) in adults but have not been studied in children.ObjectiveTo identify whether children and adolescents with asthma had less severe disease and lower morbidity from COVID-19 than their counterparts without asthma.MethodsThis was a retrospective chart review from March 1, 2020, through January 31, 2021. Charts were eligible for inclusion if patients were over 6 years of age and below 20 years of age and tested positive for COVID-19 by PCR or antigen testing or were COVID-19 antibody positive when they presented to the emergency department (ED). Patients were grouped according to disease severity and divided into two groups, those with asthma and those without. A total of 1,585 patients were included—1,492 without asthma and 93 with asthma.ResultsChildren and adolescents with asthma are less likely to be seen in the ED for COVID-19–related disease (p value< 0.0001, but if they presented to the ED, they were significantly more likely to be hospitalized, require oxygen, and have more severe forms of COVID-19 than children and adolescents without asthma (p value< 0.0001).ConclusionsChildren and adolescents with asthma, though less likely to be seen in ED with COVID-19, were more likely to have severe disease than patients without asthma, once they presented to the ED.